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SYNUCLEIN: 作品数：27被引量：33H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：余舒扬张兰王方李林左丽君更多>>; 相关机构：首都医科大学附属北京天坛医院首都医科大学宣武医院中国科学院苏州大学附属第二医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金吉林省科委基金国家重点基础研究发展计划卫生部科学研究基金更多>>

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment: 《Neural Regeneration Research》2025年第9期2598-2610,共13页Yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming Ji Jia Liu; supported by the Scientific Research Project of China Rehabilitation Research Center,No.2021zx-23;the National Natural Science Foundation of China,No.32100925;the Beijing Nova Program,No.Z211100002121038。; Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this condition.The aims of this study were to...; 关键词：BIOMARKER high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

Neural stem cells for Parkinson’s disease management:Challenges,nanobased support,and prospects被引量：1: 《World Journal of Stem Cells》2023年第7期687-700,共14页Tuba Oz Ajeet Kaushik Małgorzata Kujawska; Supported by Narodowe Centrum Nauki,No.2021/42/E/NZ7/00246.; Parkinson’s disease(PD),characterized by loss of nigrostriatal dopaminergic neurons,is one of the most predominant neurodegenerative diseases affecting the elderly population worldwide.The concept of stem cell therap...; 关键词：Parkinson’s disease SYNUCLEIN Neural stem cells NANOMATERIALS Nano-stem cell therapy

Pathophysiological significance of increased α-synuclein deposition in sympathetic nerves in Parkinson’s disease: a post-mortem observational study: 《Translational Neurodegeneration》2022年第1期737-746,共10页Risa Isonaka Patti Sullivan David S.Goldstein; the National Institutes of Health(NIH);the Intramural Research Program of the NIH,NINDS.; Background: Parkinson’s disease (PD) is characterized by intra-neuronal deposition of the protein α-synuclein (α-syn) and by deficiencies of the catecholamines dopamine and norepinephrine (NE) in the brain and hear...; 关键词：SYNUCLEIN Tyrosine hydroxylase NOREPINEPHRINE IMMUNOFLUORESCENCE PARKINSON POST-MORTEM

Chimera RNA interference knockdown of γ-synuclein in human cortical astrocytes results in mitotic catastrophe: 《Neural Regeneration Research》2020年第10期1894-1902,共9页Timmy Le Cynthia L.Winham Fotis Andromidas Adam C.Silver Evan R.Jellison Aime A.Levesque Andrew O.Koob; supported by grants from the Connecticut Partnership in Innovation and Education(PIE)Fellowship(to TL);the University of Hartford College of Arts and Sciences Dean’s Fund(to TL,FA,AOK); Elevated levels of γ-synuclein(γ-syn)expression have been noted in the progression of glioblastomas,and also in the cerebrospinal fluid of patients diagnosed with neurodegenerative diseases.γ-Syn can be either inte...; 关键词：apoptosis ASTROCYTE cell cycle GLIOBLASTOMAS phospho-histone H3 proliferation SYNUCLEIN

Stem cell therapy for Parkinson’s disease: safety and modeling被引量：6: 《Neural Regeneration Research》2020年第1期36-40,共5页Theo Stoddard-Bennett Renee Reijo Pera; supported by the Mallett Family; For decades,clinicians have developed medications and therapies to alleviate the symptoms of Parkinson’s disease,but no treatment currently can slow or even stop the progression of this localized neurodegeneration.Fo...; 关键词：alpha SYNUCLEIN animal model cell therapy DOPAMINERGIC neurons induced PLURIPOTENT STEM CELLS NEURODEGENERATION Parksinson’s disease STEM CELLS

Targeting prion-like protein spreading in neurodegenerative diseases: 《Neural Regeneration Research》2018年第11期1875-1878,共4页Zhaohui Zhang Shuke Nie Liam Chen; The infectious template-mediated protein conversion is a unique mechanism for the onset of rare and fatal neurodegenerative disorders known as transmissible spongiform encephalopathies, or prion diseases, which affect...; 关键词：prion-like SYNUCLEIN tau TAR DNA-binding protein 43 BETA-AMYLOID Parkinson＇s disease frontotemporal dementia amyotrophic lateral sclerosis Alzheimer＇s disease NEURODEGENERATION

Impacts of increased α-synuclein on clathrin-mediated endocytosis at synapses:implications for neurodegenerative diseases被引量：1: 《Neural Regeneration Research》2018年第4期647-648,共2页Audrey T.Medeiros Luigi Bubacco Jennifer R.Morgan; supported by a grant from National Institutes of Health(NINDS/NIA R01NS078165 to JRM);research funds from the Marine Biological Laboratory(to JRM);a research grant from Horizon 2020 Grant No.In Cure EU Joint Programme-JPND(to LB); α-Synuclein causes synaptic pathologies in several neurodegenerative diseases：Parkinson’s disease（PD）is a neurodegenerative disease that impacts the lives of millions of people worldwide.A pathological hallmark o...; 关键词：synuclein on clathrin-mediated endocytosis at synapses:implications for neurodegenerative diseases Impacts of increased

Iron, Dopamine, and α-Synuclein Interactions in at-Risk Dopaminergic Neurons in Parkinson's Disease被引量：13: 《Neuroscience Bulletin》2018年第2期382-384,共3页Ning Song Junxia Xie; supported by grants from the National Natural Science Foundation of China(81430024,31771124,31571054,and 31371081);Excellent Innovative Team of Shandong Province and Taishan Scholars Construction Project; Parkinson’s disease(PD)is recognized as the second most common neurodegenerative disorder after Alzheimer disease.Although a fascinating 200-year journey of research has revealed the multifaceted nature of PD[1,2],it...; 关键词：In Synuclein Interactions in at-Risk Dopaminergic Neurons in Parkinson’s Disease and DOPAMINE

趋化因子CC配基2对α?Synuclein诱导的小胶质细胞增殖及神经元凋亡的影响被引量：1: 《中国实用神经疾病杂志》2017年第24期7-12,共6页张黎军赵盼盼赵建华王超伟李青随瑞斌袁彬; 河南省科技厅科技攻关项目;编号:172102310685; 目的探讨趋化因子CC配基2(CCL2)对α?突触核蛋白(α?Synuclein)介导的小胶质细胞增殖及神经元凋亡的影响。方法体外分离培养原代小胶质细胞和原代神经元。小胶质细胞分为4组,依次为对照组、CCL2组、α?Synuclein组、CCL2+α?Synuclein...; 关键词：小胶质细胞神经元 CCL2 凋亡信号通路小鼠

姜黄素对α-突触核蛋白基因突变或过表达诱导的寡聚体形成及线粒体ATP敏感性钾离子通道的影响: 《中华医学遗传学杂志》2015年第4期462-467,共6页陈涛邓益东廖小平赵建农文国强翁国虎马飞郑莹莹; 国家自然科学基金（81060096）; 目的探讨姜黄素对r突触核蛋白（a-synuclein）寡聚体形成、线粒体膜电位及线粒体ATP敏感性钾通道（mitochondrial ATP-sensitive potassium channels，mitoKATP）的影响。方法构建野生型、A53T突变型{1-synuclein真核表达质粒，用脂质...; 关键词：α—synuclein基因姜黄素线粒体ATP敏感性钾离子通道帕金森病

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