N_(1)-苯基-1,2,3-三氮唑类熊果酸衍生物的设计与合成  

Design and Synthesis of N_(1)-phenyl-1,2,3-triazole Ursolic Acid Derivatives

作　　者：魏艳洁 赵宪东 王欢欢[1] 贾宇梦 隋丽丽[1] 张大军[1] 栾天 王进 Wei Yanjie;Zhao Xiandong;Wang Huanhuan;Jia Yumeng;Sui Lii;Zhang Dajun;Luan Tian;Wang Jin(Department of Pharmacy,Shenyang Medical College,Shenyang,Liaoning 110034,China)

机构地区：[1]沈阳医学院药学院,辽宁沈阳110034

出　　处：《化工与医药工程》2023年第4期35-39,共5页Chemical and Pharmaceutical Engineering

基　　金：辽宁省教育厅一般项目(LJKMZ20221801);辽宁省教育厅青年项目(LJKQZ20222274);辽宁省博士科研启动基金(2022-BS-341);沈阳医学院大学生科研立项项目(S202210164009,X202210164018);沈阳医学院博士科研启动基金资助项目(20205041)。

摘　　要：以不同取代的苯胺为原料,经还原、叠氮化、Click环合、氧化反应得到不同取代的N_(1)-苯基-1,2,3-三氮唑目标中间体,再将其分别与3-羰基熊果酸通过克莱森-施密特缩合反应得到目标产物。经Scifinder数据库查询,所有终产物均为新化合物,其化学结构经核磁共振氢谱、核磁共振碳谱以及质谱的联合确证。合成路线可为三唑类熊果酸衍生物的合成提供借鉴,并为开发三唑类天然产物衍生物提供参考。Different substituted N_(1)-phenyl-1,2,3-triazole target intermediates were obtained from different substituted aniline through reduction,azide,Click cyclization and oxidation reactions,and then they were respectively combined with 3-carbonyl Ursolic acid to obtain the target products through Clarison Schmidt Condensation reaction.According to the Scifinder database query,all the end products were new compounds,and their chemical structures were jointly confirmed by Proton nuclear magnetic resonance,nuclear magnetic resonance carbon spectrum and mass spectrometry.This synthetic route can provide a reference for the synthesis of triazole derivatives of Ursolic acid,and provide a reference for the development of triazole derivatives of Natural product.

关 键 词：熊果酸 1 2 3-三氮唑 合成 

分 类 号：R914[医药卫生—药物化学]