Metabotropic glutamate receptors(mGluRs)in epileptogenesis:an update on abnormal mGluRs signaling and its therapeutic implications  

作　　者：Leyi Huang Wenjie Xiao Yan Wang Juan Li Jiaoe Gong Ewen Tu Lili Long Bo Xiao Xiaoxin Yan Lily Wan 

机构地区：[1]Department of Anatomy and Neurobiology,Central South University Xiangya Medical School,Changsha,Hunan Province,China [2]Department of Neurology,Xiangya Hospital,Central South University,Changsha,Hunan Province,China [3]Department of Neurology,Hunan Children’s Hospital,Changsha,Hunan Province,China [4]Department of Neurology,Brain Hospital of Hunan Province,Changsha,Hunan Province,China

出　　处：《Neural Regeneration Research》2024年第2期360-368,共9页中国神经再生研究（英文版）

基　　金：supported by the Natural Science Foundation of Hunan Province,No.2021JJ30389(to JG);the Key Research and Development Program of Hunan Province of China,Nos.2022SK2042(to LL)and 2020SK2122(to ET)。

摘　　要：Epilepsy is a neurological disorder characterized by high morbidity,high recurrence,and drug resistance.Enhanced signaling through the excitatory neurotransmitter glutamate is intricately associated with epilepsy.Metabotropic glutamate receptors(mGluRs)are G protein-coupled receptors activated by glutamate and are key regulators of neuronal and synaptic plasticity.Dysregulated mGluR signaling has been associated with various neurological disorders,and numerous studies have shown a close relationship between mGluRs expression/activity and the development of epilepsy.In this review,we first introduce the three groups of mGluRs and their associated signaling pathways.Then,we detail how these receptors influence epilepsy by describing the signaling cascades triggered by their activation and their neuroprotective or detrimental roles in epileptogenesis.In addition,strategies for pharmacological manipulation of these receptors during the treatment of epilepsy in experimental studies is also summarized.We hope that this review will provide a foundation for future studies on the development of mGluR-targeted antiepileptic drugs.

关 键 词：antiepileptic drugs EPILEPTOGENESIS metabotropic glutamate receptors(mGluRs) signal pathways therapeutic potentials 

分 类 号：R742.1[医药卫生—神经病学与精神病学]