分析咖啡因的不同维持量治疗肥胖阻塞性睡眠呼吸暂停综合征患者的疗效  

Analysis of Different Maintenance Amounts of Caffeine in the Treatment of Obese Obstructive Sleep Apnea Syndrome Patient′s Efficacy

作　　者：李范 LI Fan(The Second People′s Hospital of Hefei,Hefei 230000,China)

机构地区：[1]安徽省合肥市第二人民医院,合肥230000

出　　处：《世界睡眠医学杂志》2023年第5期1177-1178,1182,共3页World Journal of Sleep Medicine

摘　　要：目的:分析咖啡因的不同维持量治疗肥胖阻塞性睡眠呼吸暂停综合征患者的疗效。方法:选取2019年1月至2022年12月安徽省合肥市第二人民医院收治的肥胖阻塞性睡眠呼吸暂停综合征患者120例作为研究对象,按照随机数字表法分为观察组和对照组,每组60例。观察组给予15 mg/kg的维持剂量咖啡因进行治疗,对照组给予5 mg/kg的维持剂量咖啡因进行治疗,观察2组患者治疗后的临床疗效,并比较2组患者治疗后3 d后的恢复情况,包括呼吸暂停次数、发作维持时长、症状消退时长以及住院时长情况。结果:经过咖啡因的不同维持量治疗后,观察组总有效率显著高于对照组,观察组的呼吸暂停次数、发作维持时长、症状消退时长均显著低于对照组,差异均有统计学意义(均P<0.05)。结论:高维持剂量的咖啡因对治疗肥胖阻塞性睡眠呼吸暂停综合征患者的疗效更为显著,能够有效减少呼吸暂停的发作次数,减轻病情严重程度,值得在临床中应用并推广。Objective:To analyze the different maintenance amounts of caffeine in the treatment of obese obstructive sleep apnea syndrome patient′s efficacy.Methods:A total of 120 obese patients with obstructive sleep apnea syndrome admitted to the Second People′s Hospital of Hefei,Anhui Province from January 2019 to December 2022 were selected as research objects,and were divided into observation group and control group according to the random number table method,with 60 cases in each group.The observation group was given a maintenance dose of 15 mg/kg caffeine for treatment,and the control group was given a maintenance dose of 5 mg/kg caffeine for treatment.The clinical efficacy of the two groups after treatment was observed,and the recovery of the two groups after 3 days after treatment was compared,including the number of apnea,duration of seizure,duration of symptom resolution and length of hospital stay.Results:After treatment with different maintenance amounts of caffeine,the total effective rate of the observation group was significantly higher than the control group,and the frequency of apnea,duration of attack and duration of symptom resolution in the observation group were significantly lower than the control group,the differences between the two groups were statistically significant(P s<0.05).Conclusion:High maintenance dose of caffeine is more effective in the treatment of obese patients with obstructive sleep apnea syndrome,which can effectively reduce the number of apnea episodes and reduce the severity of the disease,and is worthy of clinical application and promotion.

关 键 词：咖啡因 维持量 肥胖 睡眠呼吸暂停 疗效 

分 类 号：R364.4[医药卫生—病理学] R338.63[医药卫生—基础医学]