MXRA7 is involved in megakaryocyte differentiation and platelet production  

作　　者：Zhenjiang Sun Benfang Wang Ying Shen Kunpeng Ma Ting Wang Yiqiang Wang Dandan Lin 

机构地区：[1]Institute of Blood and Marrow Transplantation,National Clinical Research Center for Hematologic Diseases,Collaborative Innovation Center of Hematology,Jiangsu Institute of Hematology,The First Affiliated Hospital of Soochow University,Suzhou Medical College,Soochow University,Suzhou 215006,China [2]Department of Clinical Laboratory,The Affiliated Jiangyin Hospital of Southeast University,Jiangyin 214400,China [3]Wisdom Lake Academy of Pharmacy,Xi’an Jiaotong-Liverpool University,Suzhou 215123,China

出　　处：《Blood Science》2023年第3期160-169,共10页血液科学（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(81600076,81271050,82070186);Suzhou Science and Technology Program Project(SKY2022043);the Innovation special project of science and technology of Jiangyin(JY0603A021014210012).

摘　　要：Matrix remodeling is a critical process in hematopoiesis.The biology of MXRA7,as a matrix remodeling associated gene,has still not been reported in hematopoietic process.Public databases showed that MXRA7 expressed in hematopoietic stem cells,suggesting that it may be involved in hematopoiesis.We found that the amounts of megakaryocytes were lower in bone marrow and spleen from Mxra7−/−mice compared with that from wild-type mice.Knock-out of MXRA7 also reduced the amount of platelet in peripheral blood and affected the function of platelets.Knock-out of MXRA7 inhibited hematopoietic stem/progenitor cells differentiate to megakaryocytes possibly through down-regulating the expression of GATA-1 and FOG-1.Moreover,knockdown of MXRA7 in MEG-01 cells could inhibit the cell proliferation and cell apoptosis.Knockdown of MXRA7 inhibited the differentiation of MEG-01 cells and proplatelet formation through suppressing the ERK/MAPK signaling pathway and the expression ofβ-tubulin.In conclusion,the current study demonstrated the potential significance of MXRA7 in megakaryocyte differentiation and platelet production.The novel findings proposed a new target for the treatment of platelet-related diseases,and much more investigations are guaranteed to dissect the mechanisms of MXRA7 in megakaryocyte differentiation and platelet production.

关 键 词：DIFFERENTIATION MEGAKARYOCYTES MXRA7 PLATELET 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]