MEGAKARYOCYTES

作品数：9被引量：14H指数：2
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相关领域：医药卫生更多>>
相关作者：刘津麟吴茅更多>>
相关机构：浙江省人民医院中国医学科学院血液病医院(血液学研究所)更多>>
相关期刊：《Frontiers of Medicine》《Chinese Journal of Integrative Medicine》《Blood Science》《Military Medical Research》更多>>
相关基金：国家自然科学基金更多>>
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Versatility of megakaryocytes in homeostasis and disease
《Blood Science》2024年第4期22-26,共5页Daosong Wang Jiayi Xie Meng Zhao 
supported in part by the National Key Research and Development Program of China(2022YFA1104100);the National Natural Science Foundation of China(82325002).
Megakaryocytes(MKs)constitute a small portion of bone marrow cells and are primarily responsible for producing platelets,which are essential for hemostasis and wound healing.Recent studies have revealed that MKs and p...
关键词：Aging Hematopoietic stem cell Immune responses MEGAKARYOCYTE NICHE PLATELET 
Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury
《Military Medical Research》2024年第6期797-817,共21页Chang-Hong Du Yi-Ding Wu Ke Yang Wei-Nian Liao Li Ran Chao-Nan Liu Shu-Zhen Zhang Kuan Yu Jun Chen Yong Quan Mo Chen Ming-Qiang Shen Hong Tang Shi-Lei Chen Song Wang Jing-Hong Zhao Tian-Min Cheng Jun-Ping Wang 
supported by the Key Program of the National Natural Science Foundation of China(81930090);the National Science Foundation for Distinguished Young Scholars of China(81725019);the National Natural Science Foundation of China(32171104,82273571,and 81874256);the Chongqing Natural Science Foundation(2023NSCQ-MSX0687,CSTB2023NSCQ-JQX0015,and cstc2015jcyjys10001);the Chongqing Talent Program(CQYC20220511002).
Background:The essential roles of platelets in thrombosis have been well recognized.Unexpectedly,thrombosis is prevalent during thrombocytopenia induced by cytotoxicity of biological,physical and chemical origins,whic...
关键词：Radiation injury THROMBOCYTOPENIA Platelet size Platelet hyperreactivity Megakaryocytes(MKs) 
Immunological face of megakaryocytes
《Frontiers of Medicine》2024年第6期988-1001,共14页Yueying Li Kunying Chen Qian-Fei Wang 
supported by Beijing Natural Science Foundation(No.JQ21024);the National Natural Science Foundation of China(Nos.82350004,82130008 and 82170125);the Youth Innovation Promotion Association,Chinese Academy of Sciences(No.Y2021037);Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(No.CI2023C027YL).
Megakaryocytes(MKs),which are traditionally known for their role in platelet production,are now emerging as unique immune cells with diverse capabilities.They express immune receptors,participate in pathogen recogniti...
关键词：MEGAKARYOCYTE PLATELET IMMUNE inflammation HETEROGENEITY 
MXRA7 is involved in megakaryocyte differentiation and platelet production
《Blood Science》2023年第3期160-169,共10页Zhenjiang Sun Benfang Wang Ying Shen Kunpeng Ma Ting Wang Yiqiang Wang Dandan Lin 
supported by grants from the National Natural Science Foundation of China(81600076,81271050,82070186);Suzhou Science and Technology Program Project(SKY2022043);the Innovation special project of science and technology of Jiangyin(JY0603A021014210012).
Matrix remodeling is a critical process in hematopoiesis.The biology of MXRA7,as a matrix remodeling associated gene,has still not been reported in hematopoietic process.Public databases showed that MXRA7 expressed in...
关键词：DIFFERENTIATION MEGAKARYOCYTES MXRA7 PLATELET 
Ultrastructural alterations of megakaryocytes in thrombocytopenia:A review of 43 cases
《Blood Science》2022年第1期47-47,共1页
In the article titled“Ultrastructural alterations of megakaryocytes in thrombocytopenia:A review of 43 cases,”published on pages 107–112,Volume 3,Issue 4 of Blood Science,1 a coauthor’s name was incorrectly publis...
关键词：BLOOD cytes alterations 
Ultrastructural alterations of megakaryocytes in thrombocytopenia:A review of 43 cases被引量：1
《Blood Science》2021年第4期107-112,共6页Brian Eyden Yong-Xin Ru Shu-Xu Dong Jing Liu Xiao-Fan Liu 
Thrombocytopenia is a frequent occurrence in a variety of hematopoietic diseases;however,the details of the mechanism leading to low platelet count remain elusive.Megakaryocytes are a series of progenitor cells respon...
关键词：Blood disease MEGAKARYOCYTE PLATELET THROMBOCYTOPENIA ULTRASTRUCTURE 
Loss of Tet2 affects platelet function but not coagulation in mice
《Blood Science》2020年第4期129-136,共8页Bichen Wang Meijuan Xia Ting Chen Mengke Li Deyang Shi Xiaomin Wang Aiming Pang Jiaxi Zhou Weiping Yuan Yajing Chu 
This work was partially supported by the funds from the CAMS Innovation Fund for Medical Sciences(2016-I2M-1-017 and 2017-I2M-3-015);National Natural Science Foundation of China(81629001,81421002,81600136,81770105,81970149).
Ten-eleven translocation 2(TET2)functions as a methylcytosine dioxygenase that catalyzes the iterative oxidation of 5-methylcytosine to 5-hydroxymethylcytosine,5-formylcytosine and 5-carboxylcytosine.TET2 has been sho...
关键词：MEGAKARYOCYTES Mouse Mutation PLATELET Tet2 THROMBOSIS 
Effects of Panaxadiol Saponins Component as A New Chinese Patent Medicine on Proliferation,Differentiation and Corresponding Gene Expression Profile of Megakaryocytes被引量：11
《Chinese Journal of Integrative Medicine》2016年第1期28-35,共8页温伟为 孙馨 庄海峰 林筱洁 郑智茵 高瑞兰 尹利明 
Supported by National Natural Science Foundation of China(No.81373876);Zhejiang Provincial Natural Science Foundation(No.LY14H290004);Science and Technology Program of Zhejiang Province(No.2010C33098)
Objective： To investigate the effects of panaxadiol saponins component （PDS-C） isolated from total saponins of panax ginseng on proliferation, differentiation and corresponding gone expression profile of megakaryoc...
关键词：panaxadiol saponins MEGAKARYOCYTE gene expression profile PROLIFERATION DIFFERENTIATION 
Effects of human immunodeficiency virus on the erythrocyte and megakaryocyte lineages被引量：2
《World Journal of Virology》2013年第2期91-101,共11页Davide Gibellini Alberto Clò Silvia Morini Anna Miserocchi Cristina Ponti Maria Carla Re 
Supported by Funds from Fondazione Cassa di Risparmio Bologna,Italy,No.2006.0035;Fondazione del Monte di Bologna e Ravenna,Italy,No.376 bis;"AIDS projects"of the Italian Ministry of Health,No.40H5;Funds for Selected Research Topics of the University of Bologna and MURST 60%
Anaemia and thrombocytopenia are haematological disorders that can be detected in many human immunodeficiency virus(HIV)-positive patients during the development of HIV infection. The progressive decline of erythrocyt...
关键词：Human immunodeficiency virus Erythrocytes MEGAKARYOCYTES Haematopoietic PROGENITOR cells VIROLOGY 
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