Effects of human immunodeficiency virus on the erythrocyte and megakaryocyte lineages  

作　　者：Davide Gibellini Alberto Clò Silvia Morini Anna Miserocchi Cristina Ponti Maria Carla Re 

机构地区：[1]Department of Haematology and Oncological Sciences, Microbiology Section, University of Bologna [2]Department of Life Sciences, University of Trieste [3]Interuniversity Consortium, National Institute Biostructure and Biosystems

出　　处：《World Journal of Virology》2013年第2期91-101,共11页世界病毒学杂志

基　　金：Supported by Funds from Fondazione Cassa di Risparmio Bologna,Italy,No.2006.0035;Fondazione del Monte di Bologna e Ravenna,Italy,No.376 bis;"AIDS projects"of the Italian Ministry of Health,No.40H5;Funds for Selected Research Topics of the University of Bologna and MURST 60%

摘　　要：Anaemia and thrombocytopenia are haematological disorders that can be detected in many human immunodeficiency virus(HIV)-positive patients during the development of HIV infection. The progressive decline of erythrocytes and platelets plays an important role both in HIV disease progression and in the clinical and therapeutic management of HIV-positive patients. HIV-dependent impairment of the megakaryocyte and erythrocyte lineages is multifactorial and particularly affects survival, proliferation and differentiation of bone marrow(BM) CD34+ haematopoietic progenitor cells, the activity of BM stromal cells and the regulation of cytokine networks. In this review, we analyse the ma-jor HIV-related mechanisms that are involved in the genesis and development of the anaemia and thrombocytopenia observed in HIV positive patients.Anaemia and thrombocytopenia are haematological disorders that can be detected in many human immunodeficiency virus(HIV)-positive patients during the development of HIV infection. The progressive decline of erythrocytes and platelets plays an important role both in HIV disease progression and in the clinical and therapeutic management of HIV-positive patients. HIV-dependent impairment of the megakaryocyte and erythrocyte lineages is multifactorial and particularly affects survival, proliferation and differentiation of bone marrow(BM) CD34+ haematopoietic progenitor cells, the activity of BM stromal cells and the regulation of cytokine networks. In this review, we analyse the ma-jor HIV-related mechanisms that are involved in the genesis and development of the anaemia and thrombocytopenia observed in HIV positive patients.

关 键 词：Human immunodeficiency virus Erythrocytes MEGAKARYOCYTES Haematopoietic PROGENITOR cells VIROLOGY 

分 类 号：R[医药卫生]