Mechanisms of insulin resistance in obesity  

作　　者：Jianping Ye 

机构地区：[1]Antioxidant and Gene Regulation Laboratory,Pennington Biomedical Research Center,Louisiana State University System,Baton Rouge,LA70808,USA

出　　处：《Frontiers of Medicine》2013年第1期14-24,共11页医学前沿（英文版）

基　　金：Jianping Ye is supported by the National Institute of Health research projects(DK085495,DK068036).

摘　　要：Obesity increases the risk for type 2 diabetes through induction of insulin resistance.Treatment of type 2 diabetes has been limited by little translational knowledge of insulin resistance although there have been several well-documented hypotheses for insulin resistance.In those hypotheses,inflammation,mitochondrial dysfunction,hyperinsulinemia and lipotoxicity have been the major concepts and have received a lot of attention.Oxidative stress,endoplasmic reticulum(ER)stress,genetic background,aging,fatty liver,hypoxia and lipodystrophy are active subjects in the study of these concepts.However,none of those concepts or views has led to an effective therapy for type 2 diabetes.The reason is that there has been no consensus for a unifying mechanism of insulin resistance.In this review article,literature is critically analyzed and reinterpreted for a new energy-based concept of insulin resistance,in which insulin resistance is a result of energy surplus in cells.The energy surplus signal is mediated by ATP and sensed by adenosine monophosphate-activated protein kinase(AMPK)signaling pathway.Decreasing ATP level by suppression of production or stimulation of utilization is a promising approach in the treatment of insulin resistance.In support,many of existing insulin sensitizing medicines inhibit ATP production in mitochondria.The effective therapies such as weight loss,exercise,and caloric restriction all reduce ATP in insulin sensitive cells.This new concept provides a unifying cellular and molecular mechanism of insulin resistance in obesity,which may apply to insulin resistance in aging and lipodystrophy.

关 键 词：type 2 diabetes energy expenditure inflammation LIPOTOXICITY MITOCHONDRIA HYPERINSULINEMIA adenosine monophosphate-activated protein kinase(AMPK) 

分 类 号：R58[医药卫生—内分泌]