Preliminary results of gentamycin combined with sodium bicarbonate for prevention of irinotecan-induced diarrhea  

作　　者：Qi MEI Zhe CAO Hua XIONG Yuan CHEN 

机构地区：[1]The Cancer Center of Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

出　　处：《Frontiers of Medicine》2009年第4期470-474,共5页医学前沿（英文版）

摘　　要：The aim of this paper was to observe the clinical effect of gentamycin combined with sodium bicarbonate for the prevention of irinotecan-induced diarrhea.A total of 98 patients with stage IV cancers were recruited and divided into a prevention group(52 patients)and a control group(46 patients).All patients received the chemotherapy including irinotecan.The prevention group received gentamycin and sodium bicarbonate before the use of irinotecan for 4 days;the control group did not receive any prevention.The use of gentamycin and sodium bicarbonate resulted in signifi-cantly higher stool pH(P<0.001),while the incidence of diarrhea by irinotecan was reduced(prevention group 13.70%versus control group 34.83%;P<0.001).Genta-mycin combined with sodium bicarbonate appears to be useful in preventing the diarrhea induced by irinotecan and reducing the dosage of loperamide andfluid replacement.

关 键 词：IRINOTECAN DIARRHEA GENTAMYCIN sodium bicarbonate PREVENTION 

分 类 号：R73[医药卫生—肿瘤]