Taurine: a promising nutraceutic in the prevention of retinal degeneration  

作　　者：Diego García-Ayuso Johnny Di Pierdomenico Ana Martínez-Vacas Manuel Vidal-Sanz Serge Picaud María PVillegas-Pérez 

机构地区：[1]Grupo de Investigación Oftalmología Experimental,Departamento de Oftalmología,Optometría,Otorrinolaringología y Anatomía Patológica,Facultad de Medicina,Universidad de Murcia,Instituto Murciano de Investigación Biosanitaria(IMIB),Campus de Ciencias de la Salud,Murcia,España [2]Sorbonne Université,INSERM,CNRS,Institut de la Vision,Paris,France

出　　处：《Neural Regeneration Research》2024年第3期606-610,共5页中国神经再生研究（英文版）

基　　金：supported by Instituto de Salud CarlosⅢ(ISCⅢ):PI19/00203;cofunded by ERDF;"A way to make Europe"to MPVP and DGA;P122/00900;RD16/0008/0026 co-funded by ERDF;"A way to make Europe"to MPVP and RD21/0002/0014;financiado porla Unión Europea-NextGenerationEU;Fundación Robles Chillida to DGA;RED2018-102499-T;PID201 9-106498GB-I00;funded by MCIN/AEI/10.13039/501100011 033 to MVS;IHU FOReSIGHT[ANR-18-IAHU-0001] to SP

摘　　要：Taurine is considered a non-essential amino acid because it is synthesized by most mammals.However,dietary intake of taurine may be necessary to achieve the physiological levels required for the development,maintenance,and function of certain tissues.Taurine may be especially important for the retina.The concentration of taurine in the retina is higher than that in any other tissue in the body and taurine deficiency causes retinal oxidative stress,apoptosis,and degeneration of photoreceptors and retinal ganglion cells.Low plasma taurine levels may also underlie retinal degeneration in humans and therefore,taurine administration could exert retinal neuroprotective effects.Taurine has antioxidant,anti-apoptotic,immunomodulatory,and calcium homeostasis-regulatory properties.This review summarizes the role of taurine in retinal health and disease,where it appears that taurine may be a promising nutraceutical.

关 键 词：amino acid ANTI-INFLAMMATORY ANTIOXIDANT gamma-aminobutyric acid NUTRACEUTICAL photoreceptor degeneration RETINA retinitis pigmentosa TAURINE 

分 类 号：R774.1[医药卫生—眼科]