纳米淀粉的疏水改性及其对叶黄素的吸附研究  

Hydrophobic Modification of Nanometer Starch and Adsorption of Lutein

作　　者：史永桂 姚先超 焦思宇 陆晓娜 杨麦秋 林日辉 SHI Yonggui;YAO Xianchao;JIAO Siyu;LU Xiaona;YANG Maiqiu;LIN Rihui(School of Chemistry and Chemical Engineering,Guangxi Minzu University,Guangxi Key Laboratory Cultivation Base for Polysaccharide Materials and Modifications,Key Laboratory of Chemistry and Engineering of Forest Products,State Ethnic Affairs Commission,Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products,Gungxi Minzu University,Nanning 530006,China)

机构地区：[1]广西民族大学化学化工学院,广西多糖材料与改性重点实验室,林产化学与工程国家民委重点实验室,广西林产化学与工程重点实验室/协同创新中心,广西南宁530006

出　　处：《食品工业科技》2023年第17期42-50,共9页Science and Technology of Food Industry

基　　金：国家自然科学基金项目(21766004);广西自然科学基金项目(2019GXNSFAA185008)。

摘　　要：目的:为提升淀粉在载药领域的应用,旨在制备出纳米级疏水改性淀粉,研究其对疏水性药物的负载效果。方法:以木薯淀粉为原料,采用沉降法制备了纳米淀粉(Nanometer Starch,SNPs),并以脂肪酶为催化剂,在两相体系对SNPs催化改性,合成了不同取代度(Degree of Substitution,DS)的松香酯纳米淀粉(Rosin Ester Nanometer Starch,RENPS),考察了SNPs和RENPS在不同条件下对叶黄素的吸附效果。结果:酯化改性未对SNPs形貌产生显著影响,SNPs尺寸分布在250~800 nm,主峰为480 nm,RENPS尺寸分布在100~800 nm,DS的增加,使主峰向左移动;DS与RENPS的疏水性呈现正相关,RENPS的接触角可达93.32°±1.15°,SNPs的接触角仅为51.69°±2.15°。随着DS的增加,RENPS对叶黄素吸附达到平衡的时间逐渐减小,但吸附量逐渐增加。SNPs对叶黄素吸附为一级动力学,RENPS对叶黄素吸附为二级动力学。结论:本研究确定了RENPS的一种疏水改性方法,并且改性后的RENPS对疏水性药物的负载能力得到显著提升。Objects:In order to improve the application of starch in the field of drug loading,the aim was to prepare the nano hydrophobic modified starch and study its effect on hydrophobic drug loading.Methods:Nanometer starch(SNPs)was prepared using tapioca starch as a raw material by deposition method.On this basis,rosin ester nanometer starch(RENPS)with different degrees of substitution(DS)was synthesized by modifying SNPs in a two-phase system and using lipase as a catalyst.The adsorption effects of SNPs and RENPS on lutein under different conditions were investigated.Results:The results indicated that the esterification did not significantly affect the morphology of SNPs.The size of SNPs ranged from 250 nm to 800 nm,and the main peak was 480 nm.The size of RENPS ranged from 100 nm to 800 nm,and the main peak shifted from 450 nm to 100 nm with the increase of DS.There was a positive correlation between DS and the hydrophobicity of RENPS.The contact angle of RENPS could reach 93.32°±1.15°,while the contact angle of SNPs was only 51.69°±2.15°.As DS increased,the time for RENPS to reach the adsorption equilibrium of lutein decreased gradually,but the amount of adsorption increased gradually.The adsorption of lutein by SNPs was a first-order kinetics,and the adsorption of lutein by RENPS was a second-order kinetics.Conclusion:In this study,a hydrophobic modification method of RENPS was determined,and the loading capacity of modified RENPS on hydrophobic drugs was significantly improved.

关 键 词：纳米淀粉 松香酯纳米淀粉 叶黄素 吸附机理 

分 类 号：TS231[轻工技术与工程—粮食、油脂及植物蛋白工程]