基于生物信息学的蛋白质功能预测研究综述  

Survey of Bioinformatics-Based Protein Function Prediction

作　　者：李昕晖 钱育蓉[1,2,3] 岳海涛 胡月 陈嘉颖[1,2,3] 冷洪勇 马梦楠[1,2,3] LI Xinhui;QIAN Yurong;YUE Haitao;HU Yue;CHEN Jiaying;LENG Hongyong;MAMengnan(School of Software,Xinjiang University,Urumqi 830091,China;Key Laboratory of Signal Detection and Processing in Xinjiang Uygur Autonomous Region,Xinjiang University,Urumqi 830046,China;Key Laboratory of Software Engineering,Xinjiang University,Urumqi 830000,China;Laboratory of Synthetic Biology,School of Future Technology,Xinjiang University,Urumqi 830017,China;Department of Bioengineering,School of Life Science and Technology,Xinjiang University,Urumqi 830017,China;School of Computer Science,Beijing Institute of Technology,Beijing 100081,China)

机构地区：[1]新疆大学软件学院,乌鲁木齐830091 [2]新疆大学新疆维吾尔自治区信号检测与处理重点实验室,乌鲁木齐830046 [3]新疆大学软件工程重点实验室,乌鲁木齐830000 [4]新疆大学未来技术学院合成生物学实验室,乌鲁木齐830017 [5]新疆大学生命科学与技术学院生物工程系,乌鲁木齐830017 [6]北京理工大学计算机学院,北京100081

出　　处：《计算机工程与应用》2023年第16期50-62,共13页Computer Engineering and Applications

基　　金：新疆维吾尔自治区自然科学基金(2021D01C083);新疆维吾尔自治区科技厅国际合作项目(2020E01023);新疆维吾尔自治区科技计划青年科学基金(2022D01C83);国家部委重大专项;国家自然科学基金(62266043,61966035)。

摘　　要：蛋白质功能预测任务旨在为缺失功能标签的蛋白质数据提供功能注释,随着蛋白质测序技术的发展,数据库中蛋白质数量迅速增长,由于蛋白质数据的复杂性和多元性,蛋白质功能预测任务极具挑战,受到研究人员的密切关注。梳理了机器学习在蛋白质功能预测中的发展历程;对近年来的蛋白质功能预测方法进行归类与总结,分析各类算法之间的异同;最后对蛋白质功能预测存在的问题进行讨论,并对该领域的未来研究进行展望。The protein function prediction task aims to provide functional annotations for protein data with missing functional tags.With the development of protein sequencing technology,the number of proteins in the database is growing rapidly,and due to the complexity and multiplicity of protein data,the protein function prediction task is very challenging and has received close attention from researchers.In this paper,the development history of machine learning in protein function prediction is firstly reviewed.Secondly,protein function prediction methods in recent years are categorized and summarized,and the similarities and differences between various algorithms are analyzed.Finally,the problems of protein function prediction are discussed,and future research in this field is anticipated.

关 键 词：蛋白质功能预测 蛋白质序列 机器学习 生物计算 生物信息学 

分 类 号：TP391[自动化与计算机技术—计算机应用技术]