An overview of inflammation: mechanism and consequences  

作　　者：Afsar U.AHMED 

机构地区：[1]Monash University Department of Medicine,Centre for Inflammatory Diseases,Monash Medical Centre,246,Clayton Road,Clayton,VIC 3168 Australia

出　　处：《Frontiers in Biology》2011年第4期274-281,共8页生物学前沿（英文版）

摘　　要：Inflammation is an essential response provided by the immune systems that ensures the survival duringinfection and tissue injury. Inflammatory responses are essential for the maintenance of normal tissue homeostasis. Themolecular mechanism of inflammation is quite a complicated process which is initiated by the recognition of specificmolecular patterns associated with either infection or tissue injury. The entire process of the inflammatory response ismediated by several key regulators involved in the selective expression of proinflammatory molecules. Prolongedinflammations are often associated with severe detrimental side effects on health. Alterations in inflammatory responsesdue to persistent inducers or genetic variations are on the rise over the last couple of decades, causing a variety ofinflammatory diseases and pathophysiological conditions.

关 键 词：INFLAMMATION inflammatory diseases proinflammatory cytokines pattern-recognition receptors transcription factors and chromatin structure 

分 类 号：R57[医药卫生—消化系统]