贯叶金丝桃素在神经精神疾病中的作用机制研究  

Mechanism of action of Hyperforin in neuropsychiatric disorders

作　　者：张铮[1] 陈清杰[2] 吴宁华[3] ZHANG Zheng;CHEN Qingjie;WU Ninghua(Department of Clinical Medicine,Nanyang Medical College,Nanyang,Henan 473000,China;Hubei Key Laboratory of Diabetes and Angiopathy,Medicine Research Institute,Xianning Medical College,Hubei University of Science and Technology,Xianning,Hubei 437100,China;School of Basic Medical College,Xianning Medical College,Hubei University of Science and Technology,Xianning,Hubei 437100,China)

机构地区：[1]南阳医学高等专科学校临床医学系,河南南阳473000 [2]湖北科技学院医学部医药研究院糖尿病心脑血管病变湖北省重点实验室,湖北咸宁437100 [3]湖北科技学院医学部基础医学院,湖北咸宁437100

出　　处：《医药前沿》2023年第16期34-37,共4页Journal of Frontiers of Medicine

基　　金：河南省高等职业学校青年骨干教师培养计划(2020GZGG021);河南省医学科技攻关计划联合共建项目(LHGJ20200908)。

摘　　要：贯叶金丝桃素是中药贯叶金丝桃的重要活性成分,除了抗抑郁效果,贯叶金丝桃素在其他神经精神疾病中具有潜在的治疗作用。本文从其对神经递质、TRPC6、细胞因子影响等方面对现阶段贯叶金丝桃素在神经精神疾病中的作用机制进行归纳和阐述,为进一步深入研究奠定基础。Hyperforin is an important active ingredient of Hypericum perforatum L.In addition to its antidepressant effect,Hyperforin has potential therapeutic effects in other neuropsychiatric diseases.This article summarizes and elaborates the mechanism of hypericin in neuropsychiatric diseases from its effects on neurotransmitters,TRPC6,and cytokines,laying a foundation for further research.

关 键 词：贯叶金丝桃素 神经精神疾病 神经递质 TRPC6 细胞因子 

分 类 号：R741[医药卫生—神经病学与精神病学]