A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules  

作　　者：JoséManuel García-Heredia Marco Pérez Eva M.Verdugo-Sivianes María M.Martínez-Ballesteros Sara M.Ortega-Campos Amancio Carnero 

机构地区：[1]Instituto de Biomedicina de Sevilla(IBIS)/HUVR/Universidad de Sevilla/CSIC,Sevilla,Spain [2]Departamento de Bioquímica Vegetal y Biología Molecular,Universidad de Sevilla,Sevilla,Spain [3]CIBERONC,IS Carlos III,Madrid,Spain [4]Departamento de Anatomía Patológica,HUVR,Sevilla,Spain [5]Departamento de Lenguajes y Sistemas Informáticos,Escuela Superior de Ingeniería Informática,Universidad de Sevilla,Sevilla,Spain

出　　处：《Signal Transduction and Targeted Therapy》2023年第7期3221-3224,共4页信号转导与靶向治疗（英文）

基　　金：The authors thank the donors and the Hospital Universitario Virgen del Rocío-Instituto de Biomedicina de Sevilla Biobank(Andalusian Public Health System Biobank and ISCIII-Red de Biobancos y Biomodelos-ISCIII-PT20/00069)for the human specimens used in this study.This research was funded by grants from the Ministerio de Ciencia e Innovación(MCI),Plan Estatal de I+D+I 2021,Agencia Estatal de Investigación(AEI)and Fondo Europeo de Desarrollo Regional(MCI/AEI/FEDER,UE):ID2021-122629OB-I00;from CIBER de Cáncer(CB16/12/00275);co-funded by FEDER from Regional Development European Funds(European Union);from Consejería de Salud(PI-0397-2017);Project P18-RT-2501 from the 2018 competitive research projects call within the scope of PAIDI 2020 co-financed by the European Regional Development Fund(ERDF)from the Regional Ministry of Economic Transformation,Industry;Knowledge and Universities,Junta de Andalucía.Special thanks to the AECC(Spanish Association of Cancer Research)Founding Ref.GC16173720CARR for supporting this work.EMV-S is funded by a postdoctoral fellowship from Junta de Andalucía(DOC_00512).

摘　　要：Dear Editor Sarcomas are a group of heterogeneous mesodermic rare tumors with high incidence in children,reaching up to 20%of neoplasms.Standard treatment for sarcomas is surgical resection,and only some patients are treated with chemotherapy and/or radiation therapy.The 5-year relative survival rate for patients with metastatic sarcoma is only 15%.

关 键 词：NEOPLASMS CHEMOTHERAPY TREATMENT 

分 类 号：R73[医药卫生—肿瘤]