Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits  

作　　者：Liying Chen Yingwei Xu Heming Cheng Zhongxia Li Nanxi Lai Menghan Li Yeping Ruan Yang Zheng Fan Fei Cenglin Xu Jiao Ma Shuang Wang Yan Gu Feng Han Zhong Chen Yi Wang 

机构地区：[1]Institute of Pharmacology&Toxicology,College of Pharmaceutical Sciences,School of Medicine,Zhejiang University,Hangzhou,China [2]Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province,School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou,China [3]Zhejiang Rehabilitation Medical Center Department,The Third Affiliated Hospital,Zhejiang Chinese Medical University,Hangzhou,China [4]Key Laboratory of Cardiovascular&Cerebrovascular Medicine,Drug Target and Drug Discovery Center,School of Pharmacy,Nanjing Medical University,Nanjing,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第7期3427-3442,共16页信号转导与靶向治疗（英文）

基　　金：This project was supported by grants from the National Natural Science Foundation of China(82022071,81973298 and 82204350);the National Key Research and Development Program of China(2020YFA0803902);the Natural Science Foundation of Zhejiang Province(LD22H310003).

摘　　要：Temporal lobe epilepsy(TLE),one common type of medically refractory epilepsy,is accompanied with altered adult-born dentate granule cells(abDGCs).However,the causal role of abDGCs in recurrent seizures of TLE is not fully understood.Here,taking advantage of optogenetic and chemogenetic tools to selectively manipulate abDGCs in a reversible manner.

关 键 词：EPILEPSY seizures MAINTAIN 

分 类 号：R742.1[医药卫生—神经病学与精神病学]