A Kaposi’s sarcoma-associated herpes virus-encoded microRNA contributes to dilated cardiomyopathy  

作　　者：Yanru Zhao Huaping Li Hengzhi Du Zhongwei Yin Mengying He Jiahui Fan Xiang Nie Yang Sun Huiying Hou Beibei Dai Xudong Zhang Yuanyuan Cai Kunying Jin Nan Ding Zheng Wen Jiang Chang Chen Chen Dao Wen Wang 

机构地区：[1]Division of Cardiology,Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,430030 Wuhan,China [2]Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders,430030 Wuhan,China [3]Division of Cardiology,Department of Internal Medicine,Hubei Provincial Renmin Hospital,430030 Wuhan,China [4]Division of Cardiology,Department of Internal Medicine,The First People’s Hospital of Anqing,246004 Anqing,China [5]Department of Epidemiology and Biostatistics,Key Laboratory for Environment and Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,430030 Wuhan,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第7期3443-3454,共12页信号转导与靶向治疗（英文）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(nos.81822002,82270363,91839302,81630010,81790624,31771264,31800973,and 82000387);National Key R&D Program of China(no.2017YFC0909400);the Natural Science Foundation of Hubei Province(no.2020CFA016).The funders had no role in study design,data collection and analysis,manuscript preparation,or decision to publish.

摘　　要：Dilated cardiomyopathy(DCM)is the leading cause of heart transplantation.By microRNA(miRNA)array,a Kaposi’s sarcoma-associated herpes virus(KSHV)-encoded miRNA,kshv-miR-K12-1-5p,was detected in patients with DCM.The KSHV DNA load and kshv-miR-K12-1-5p level in plasma from 696 patients with DCM were measured and these patients were followed-up.

关 键 词：KAPOSI CARDIOMYOPATHY SARCOMA 

分 类 号：R542.2[医药卫生—心血管疾病]