Multifunctional glycolipids as multi-targeting therapeutics for neural regeneration  

作　　者：Yutaka Itokazu 

机构地区：[1]Department of Neuroscience and Regenerative Medicine,Medical College of Georgia,Augusta University,Augusta,GA,USA

出　　处：《Neural Regeneration Research》2024年第4期707-708,共2页中国神经再生研究（英文版）

基　　金：supported by a National Institute of Neurological Disorders and Stroke grant(R01 NS100839);a Sheffield Memorial Grant of the CSRA Parkinson’s Disease Support Group,and the excellent infrastructural support of the Department of Neuroscience and Regenerative Medicine,Medical College of Georgia at Augusta University(all to YI).

摘　　要：Many patients with neurodegenerative diseases,such as Alzheimer’s(AD)and Parkinson’s(PD)diseases suffer from disease progression without any satisfying clinical intervention,likely due to our lack of knowledge on how normal aging impacts the pathogenic mechanisms of these debilitating diseases.A growing body of literature has emerged in recent years that clearly demonstrates the involvement of glycolipids in the protein-oligomerization of neurodegenerative disorders.We hypothesize that changes in glycolipids composition are a common mechanism underlying the shift from healthy brain aging to the neuropathological processes of neurodegenerative diseases.

关 键 词：LIPIDS INVOLVEMENT diseases 

分 类 号：R741[医药卫生—神经病学与精神病学]