Pathophysiological changes of muscle after ischemic stroke:a secondary consequence of stroke injury  

作　　者：Hu Qi Dan Tian Fei Luan Ruocong Yang Nan Zeng 

机构地区：[1]State Key Laboratory of Southwestern Chinese Medicine Resources,Chengdu University of Traditional Chinese Medicine [2]School of Pharmacy,Chengdu University of Traditional Chinese Medicine [3]Acupuncture and Tuina School,Chengdu University of Traditional Chinese Medicine

出　　处：《Neural Regeneration Research》2024年第4期737-746,共10页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China for Young Scientists,No.82104732(to RY);Xinglin Scholar Project of Chengdu University of Traditional Chinese Medicine,No.BSH2020022(to RY);the Open Research Fund of Chengdu University of Traditional Chinese Medicine Key Laboratory of Systematic Research of Distinctive Chinese Medicine Resources in Southwest China,No.2020XSGG002(to NZ)。

摘　　要：Sufficient clinical evidence suggests that the damage caused by ischemic stroke to the body occurs not only in the acute phase but also during the recovery period,and that the latter has a greater impact on the long-term prognosis of the patient.However,current stroke studies have typically focused only on lesions in the central nervous system,ignoring secondary damage caused by this disease.Such a phenomenon arises from the slow progress of pathophysiological studies examining the central nervous system.Further,the appropriate therapeutic time window and benefits of thrombolytic therapy are still controversial,leading scholars to explore more pragmatic intervention strategies.As treatment measures targeting limb symptoms can greatly improve a patient’s quality of life,they have become a critical intervention strategy.As the most vital component of the limbs,skeletal muscles have become potential points of concern.Despite this,to the best of our knowledge,there are no comprehensive reviews of pathophysiological changes and potential treatments for post-stroke skeletal muscle.The current review seeks to fill a gap in the current understanding of the pathological processes and mechanisms of muscle wasting atrophy,inflammation,neuroregeneration,mitochondrial changes,and nutritional dysregulation in stroke survivors.In addition,the challenges,as well as the optional solutions for individualized rehabilitation programs for stroke patients based on motor function are discussed.

关 键 词：inflammation ischemic stroke MITOCHONDRIA muscle atrophy muscle fiber muscle nutrition quality of life rehabilitation UBIQUITIN 

分 类 号：R743.3[医药卫生—神经病学与精神病学]