Latest assessment methods for mitochondrial homeostasis in cognitive diseases  

作　　者：Wei You Yue Li Kaixi Liu Xinning Mi Yitong Li Xiangyang Guo Zhengqian Li 

机构地区：[1]Department of Anesthesiology,Peking University Third Hospital [2]Peking University Third Clinical Medical College [3]Beijing Center of Quality Control and Improvement on Clinical Anesthesia [4]Anesthesia and Perioperative Medicine Branch of China International Exchange and Promotive Association for Medical and Health Care(CPAM)

出　　处：《Neural Regeneration Research》2024年第4期754-768,共15页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.82271222(to ZL),81971012(to ZL),82071189(to XG),and 82201335(to YL);Key Clinical Projects of Peking University Third Hospital,No.BYSYZD2019027(to ZL)。

摘　　要：Mitochondria play an essential role in neural function,such as supporting normal energy metabolism,regulating reactive oxygen species,buffering physiological calcium loads,and maintaining the balance of morphology,subcellular distribution,and overall health through mitochondrial dynamics.Given the recent technological advances in the assessment of mitochondrial structure and functions,mitochondrial dysfunction has been regarded as the early and key pathophysiological mechanism of cognitive disorders such as Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,mild cognitive impairment,and postoperative cognitive dysfunction.This review will focus on the recent advances in mitochondrial medicine and research methodology in the field of cognitive sciences,from the perspectives of energy metabolism,oxidative stress,calcium homeostasis,and mitochondrial dynamics(including fission-fusion,transport,and mitophagy).

关 键 词：cognitive disorders mitochondrial dysfunction mitochondrial energy metabolism mitochondrial dynamics mitochondrial transport MITOPHAGY mitochondrial biogenesis oxidative stress calcium homeostasis 

分 类 号：R741[医药卫生—神经病学与精神病学]