Mitochondrial dysfunction and quality control lie at the heart of subarachnoid hemorrhage  

作　　者：Jiatong Zhang Qi Zhu Jie Wang Zheng Peng Zong Zhuang Chunhua Hang Wei Li 

机构地区：[1]Department of Neurosurgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University [2]Department of Neurosurgery,Nanjing Drum Tower Hospital,Clinical College of Nanjing Medical University

出　　处：《Neural Regeneration Research》2024年第4期825-832,共8页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.82130037(to CH),81971122(to CH),82171323(to WL);the Natural Science Foundation of Jiangsu Province of China,No.BK20201113(to WL)。

摘　　要：The dramatic increase in intracranial pressure after subarachnoid hemorrhage leads to a decrease in cerebral perfusion pressure and a reduction in cerebral blood flow.Mitochondria are directly affected by direct factors such as ischemia,hypoxia,excitotoxicity,and toxicity of free hemoglobin and its degradation products,which trigger mitochondrial dysfunction.Dysfunctional mitochondria release large amounts of reactive oxygen species,inflammatory mediators,and apoptotic proteins that activate apoptotic pathways,further damaging cells.In response to this array of damage,cells have adopted multiple mitochondrial quality control mechanisms through evolution,including mitochondrial protein quality control,mitochondrial dynamics,mitophagy,mitochondrial biogenesis,and intercellular mitochondrial transfer,to maintain mitochondrial homeostasis under pathological conditions.Specific interventions targeting mitochondrial quality control mechanisms have emerged as promising therapeutic strategies for subarachnoid hemorrhage.This review provides an overview of recent research advances in mitochondrial pathophysiological processes after subarachnoid hemorrhage,particularly mitochondrial quality control mechanisms.It also presents potential therapeutic strategies to target mitochondrial quality control in subarachnoid hemorrhage.

关 键 词：mitochondrial biogenesis mitochondrial dynamics mitochondrial dysfunction mitochondrial fission and fusion mitochondrial quality control MITOPHAGY subarachnoid hemorrhage 

分 类 号：R743.35[医药卫生—神经病学与精神病学]