Anti-aging and anti-carcinogenic effects of 1α,25-dihyroxyvitamin D_(3) on skin  

作　　者：Neena Philips Mikel Portillo-Esnaola Philips Samuel Maria Gallego-Rentero Tom Keller JanFranco 

机构地区：[1]Department of Biological Sciences,Fairleigh Dickinson University,Teaneck,NJ 07601,USA [2]Department of Biology,Autónoma University of Madrid(UAM),Madrid 28049,Spain [3]Instituto Ramón y Cajal de Investigación Sanitaria(IRYCIS),Madrid 28049,Spain

出　　处：《Plastic and Aesthetic Research》2022年第1期445-454,共10页整形与美容研究（英文版）

摘　　要：Photoaging and carcinogenesis are facilitated by oxidative stress,inflammation,angiogenesis,and extracellular matrix(ECM)remodeling.Oxidative effects include DNA damage,membrane oxidation,lipid peroxidation,and alterations in the expression of p53 and antioxidant enzymes.The inflammatory and angiogenesis mediators include interleukin-1,tumor necrosis factor-α,interleukin-8,transforming growth factor-β,and vascular endothelial growth factor.ECM remodeling includes alterations in the expression and organization of collagen,elastin,matrix metalloproteinases,and elastase.1α,25-dihydroxy-vitamin D_(3) has antioxidant,anti-inflammatory,and ECM regulatory properties,and can counteract the processes that facilitate photoaging and carcinogenesis.This review provides an overview of the beneficial effects of vitamin D supplementation at a molecular level,followed by a brief discussion regarding its use as a supplement.

关 键 词：Ultraviolet radiation superoxide dismutase p53 INTERLEUKINS tumor necrosis factor-α transforming growth factor-β vascular endothelial growth factor collagen ELASTIN matrix metalloproteinases 

分 类 号：R73[医药卫生—肿瘤]