牛牙样牙发病机制的研究进展  

Research progress in the pathogenesis of taurodontism

作　　者：林凌 李佩 赵玮[1] Ling Lin;Pei Li;Wei Zhao(Hospital of Stomatology,Guanghua School of Stomatology,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Stomatology,Guangzhou 510055,China)

机构地区：[1]中山大学附属口腔医院,光华口腔医学院,广东省口腔医学重点实验室,广州510055

出　　处：《中华口腔医学研究杂志（电子版）》2023年第2期75-80,共6页Chinese Journal of Stomatological Research(Electronic Edition)

基　　金：国家自然科学基金(81974146)。

摘　　要：牛牙样牙是指牙髓腔发育异常的牙齿,具体表现为磨牙的髓腔沿牙体长轴增长、牙冠长而牙根短小,且釉牙骨质界无明显狭窄。对于牛牙样牙的发病机制目前尚未完全阐明,现有的主要理论方向包括返祖现象、遗传性疾病的伴发症及牙根的异常发育。核因子I-C(nfi-c)、WNT10A、驱动蛋白家族成员4A(KIF4A)等多种生物分子亦被证明与牛牙样牙的发生密切相关。本文就目前牛牙样牙发病机制的研究进展作一综述,以利于增进临床医生对该疾病的认识并为诊断、治疗提供帮助。Taurodontism is a developmental disturbance of pulp chamber,which manifested as a large pulp chamber and short roots with a broad enamel-cenmental junction in the molar.The pathogenesis of taurodontism has not yet been fully elucidated.The main theories about the pathogenesis include atavism,concomitant symptoms of hereditary diseases and abnormal root development.Many biological molecules such as nfi-c,WNT10A and KIF4A have also been proved to be closely related to the occurrence of taurodontism.This review focuses on the etiology of taurodontism in order to promote the clinical knowledge of the diagnosis and treatment of the disease.

关 键 词：牛牙样牙 发病机制 遗传性疾病 牙根发育异常 

分 类 号：R78[医药卫生—口腔医学]