Now We Can Tame the Wild West of Controlling Astrocytes for Treating Neocortical Epilepsy  

作　　者：Yingying Tang Shuo Zhang Cenglin Xu 

机构地区：[1]Department of Pharmacy,Women’s Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China [2]Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province,School of Pharmaceutical Science,Zhejiang Chinese Medical University,Hangzhou 310053,China [3]Department of Pharmacy,The First Afliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310003,China

出　　处：《Neuroscience Bulletin》2023年第7期1189-1190,共2页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(82173796).

摘　　要：Are activated astrocytes pro-excitatory in epilepsy?The answer tends to be"yes"with cumulative evidence proposing that astrocytic activation leads to hyperexcitability through excitatory transmitter release or neuroinflammatory pathways[1-3].But a very recent study published in Nature Communications by Zhao J et al.has refreshed this viewpoint by showing that optogenetic activation of astrocytes can alleviate neocortical seizures(a type of epileptic symptom that originates in the neocortex which is part of the external surface layer of the brain)through astrocytic Na^(+)-K^(+)-ATPase in animal models[4](Fig.1).

关 键 词：EPILEPSY CORTEX activation 

分 类 号：R749.4[医药卫生—神经病学与精神病学]