γδT细胞在牙周炎中的作用及机制研究进展  

Research progress on the roles and mechanisms ofγδT cells in periodontitis

作　　者：毛佳慧 王航[1] 程磊[2] MAO Jiahui;WANG Hang;CHENG Lei(Department of Prosthodontics,West China Hospital of Stomatology Sichuan University&National Clinical Research Center for Oral Diseases&State Key Laboratory of Oral Diseases,Chengdu 610041,China;Department of Operative Dentistry and Endodontics,West China Hospital of Stomatology Sichuan University&National Clinical Research Center for Oral Diseases&State Key Laboratory of Oral Diseases,Chengdu 610041,China)

机构地区：[1]四川大学华西口腔医院修复科国家口腔疾病临床医学研究中心、口腔疾病国家重点实验室,四川成都610041 [2]四川大学华西口腔医院牙体牙髓病科、国家口腔疾病临床医学研究中心、口腔疾病国家重点实验室,四川成都610041

出　　处：《口腔疾病防治》2023年第12期896-900,共5页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金项目(82071106)。

摘　　要：牙周炎是发生于牙周支持组织中的慢性感染性疾病,菌斑微生物是其始动因子,牙周炎造成的局部炎症及牙槽骨丧失是牙齿脱落的最常见原因。白细胞介素⁃17(interleukin⁃17,IL⁃17)在牙周炎免疫反应中占有重要地位,其主要来源是辅助性T细胞17(T helpercell 17,Th17)和γδT细胞。Th17在牙周炎中的作用已被广泛论证,但直到近年γδT细胞在牙周炎中的作用才逐渐被揭示。γδT细胞是一种高度异质性的T淋巴细胞群,被认为是天然免疫和适应性免疫之间的纽带。研究发现,γδT细胞主要分布在靠近生物膜的口腔上皮中,与微生物密切作用,产生IL⁃17,招募中性粒细胞、巨噬细胞等,参与牙周炎的宿主免疫反应。γδT细胞还被证实能产生组织修复相关因子,可在牙周炎中起保护作用。本文对γδT细胞在牙周炎中的作用及机制的研究进展进行综述。Periodontitis is a chronic infectious disease that occurs in periodontal support tissues.Plaque microorganisms are its initiating factor,while local inflammation and alveolar bone loss resulting from periodontitis are the most common causes of tooth loss.Interleukin17(IL17),which plays an important role in the immune response to periodontitis,mostly originates from T helper cell 17(Th17)andγδT cells.In periodontitis,the role of Th17 cells has been demonstrated broadly,but the role ofγδT cells was not revealed until recent years.As a highly heterogeneous group of T lymphocytes,γδT cells are considered a link between innate immunity and adaptive immunity.Studies have found thatγδT cells are mostly distributed in the oral epithelium near the biofilm,where they can interact with microorganisms to produce IL17,recruit neutrophils,macrophages,etc.,and participate in the host immune response to periodontitis.They also play a role in the association between periodontitis and relevant systemic diseases.In addition,γδT cells have been proven to produce tissue repairrelated factors with a protective effect against periodontitis.The possible mechanism ofγδT cells in periodontitis is discussed in this review.

关 键 词：牙周炎 微生物群 白细胞介素17 辅助性T细胞17 ΓΔT细胞 免疫反应 免疫调节 

分 类 号：R78[医药卫生—口腔医学]