Synthesis and Antitumor Activity Evaluation of Pyrimidine Analogues Bearing Urea Moiety  

作　　者：Kunpeng Shao Xuyao Zhang Xiaosong Zhang Dengqi Xue Liying Ma Qiurong Zhang Hongmin Liu 

机构地区：[1]School of Pharmaceutical Sciences and New Drug Research&Development Center,Zhengzhou University,Zhengzhou,Henan 450001,China

出　　处：《Chinese Journal of Chemistry》2014年第5期443-447,共5页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.81172937,U1204206);China Postdoctoral Science Foundation(Nos.20100480857,201104402);New Teachers’Fund for Doctor Stations,Ministry of Education(No.20114101120013).

摘　　要：A series of 4-anilino-6-phenylpyrimidines containing urea moiety were synthesized and the structures of all products were confirmed by^(1)H NMR,^(13)C NMR and HRMS.The antiproliferative activities of these compounds were evaluated against three human tumor cell lines(MGC-803,MCF-7 and EC-109)by applying the MTT assay method.compounds 4a,4b and 6a showed the most effective activity,among which,6a was more cytotoxic than 5-fluorouracil against all tested human cancer cell lines with IC_(50) values ranging from 1.80 to 2.72μmol·L^(-1).

关 键 词：SYNTHESIS PYRIMIDINE UREA ANTITUMOR 

分 类 号：O62[理学—有机化学]