解读内质网动态重塑:网状同源结构域蛋白的泛素化促进内质网自噬并影响神经退行  

Deciphering the ER remodeling dynamics:ubiquitination of reticulon homology domain proteins fuels ER-phagy and impacts neurodegeneration

作　　者：李博然 孙启明 Boran Li;Qiming Sun(International Institutes of Medicine,The Fourth Affiliated Hospital of Zhejiang University School of Medicine,Yiwu 322000,China;Department of Biochemistry,and Department of Cardiology of Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China)

机构地区：[1]International Institutes of Medicine,The Fourth Affiliated Hospital of Zhejiang University School of Medicine,Yiwu 322000,China [2]Department of Biochemistry,and Department of Cardiology of Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China

出　　处：《Science Bulletin》2023年第15期1600-1602,共3页科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(3202501232025012,92254307,and 31970695);the Ministry of Science and Technology of the People’s Republic of China(2021YFC2700901)。

摘　　要：The endoplasmic reticulum(ER),the most expansive membrane-bound organelle within cells,acts as a cellular hub interacting with the plasma membrane and other intracellular organelles,constituting an intricate organelle-interaction network.Fundamental to cellular functions,the ER governs protein and lipid synthesis,transport,calcium ion exchange.

关 键 词：同源结构域 CONST ORGANELLE 

分 类 号：R741[医药卫生—神经病学与精神病学]