Pilot study of genome-wide DNA methylation and gene expression for treatment response to escitalopram in panic disorder  

作　　者：Zhi-Li Zou Yuan Zhang Yu-Lan Huang Jin-Yu Wang Bo Zhou Hua-Fu Chen 

机构地区：[1]Department of Psychosomatic Medicine,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 611731,Sichuan Province,China [2]Personalized Drug Therapy Key Laboratory of Sichuan Province,Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital,Chengdu 610072,Sichuan Province,China

出　　处：《World Journal of Psychiatry》2023年第8期524-532,共9页世界精神病学杂志

基　　金：Supported by The Sichuan Provincial People’s Hospital Translational Medicine Fund,No.2021LY02.

摘　　要：BACKGROUND Antidepressants,particularly selective serotonin reuptake inhibitors,are currently considered the first-line treatment for panic disorder(PD).However,little is known about the relationship between the biomarkers that may predict better treatment.AIM To compare genome-wide methylation and gene expression patterns between responsive and non-responsive patients with PD after 4 wk of escitalopram treatment.METHODS Thirty patients with PD were enrolled in this study(responders=13;nonresponders=17).All patients were assessed using the PD Severity Scale-Chinese version before and after treatment.The Illumina Infinium MethylationEPIC(850k)BeadChip for genome-wide methylation screening and mRNA sequencing was used in all patients with PD.RESULTS A total of 701 differentially methylated positions(DMPs)were found between responders and non-responders(|Δβ|≥0.06,q<0.05),and the hyper-and hypomethylated CpG sites were 511(72.9%)and 190(27.1%),respectively.Relative to non-responders,there were 59 differential transcripts,of which 20 were downregulated and 39 were upregulated(q<0.05).However,no differen tially expressed genes were identified by mRNA sequencing after correcting for multiple testing(|log2(FC)|>1,q>0.05).CONCLUSION This preliminary study showed that DMPs might be associated with the treatment response to escitalopram in PD;however,these DMPs need to be verified in large samples.

关 键 词：Panic disorder METHYLATION Expression profiling ESCITALOPRAM 

分 类 号：R749.7[医药卫生—神经病学与精神病学]