Focusing on the tetra-partite synapse in Parkinson’s disease research using human patient-derived neurons  

作　　者：Diogo Cordeiro Tchelet Stern Shani Stern 

机构地区：[1]University of Haifa,Sagol Department of Neurobiology,Haifa,Israel

出　　处：《Neural Regeneration Research》2024年第5期979-981,共3页中国神经再生研究（英文版）

基　　金：supported by the Israel Science Foundation(ISF grant 1994/21 and 3252/21);Zuckerman(Zuckerman STEM leadership program)(to SS).

摘　　要：Parkinson’s disease(PD)was first described as a neurological disease by Dr.James Parkinson in 1817 as a“shaking palsy”.Since that time,much more is known about the pathophysiology of PD yet the disease is still uncurable.The hallmark of the disease is often considered Lewy body neural inclusions in the substantia nigra pars compacta and other brain areas,although not all patients have these inclusions.The patients exhibit massive neuronal cell loss in the substantia nigra pars compacta,which is associated with the motor symptoms of tremor,bradykinesia,rigidity,and postural instability.PD is the second most common neurodegenerative disease after Alzheimer’s disease with a prevalence of around 1%of individuals over the age of 60.

关 键 词：patients ALZHEIMER Focus 

分 类 号：R742.5[医药卫生—神经病学与精神病学]