基于静息态功能连接的青少年吸烟成瘾者脑岛的变化  

Changes in the Brain Insula of Adolescent Smoking Addicts Based on Resting-state Functional Connectivity

作　　者：王晓青 薛婷 袁凯 董芳 程永欣 喻大华[1] 王娟 WANG Xiaoqing;XUE Ting;YUAN Kai;DONG Fang;CHENG Yongxin;YU Dahua;WANG Juan(School of Information Engineering,Inner Mongolia University of Science and Technology,Baotou 014010 China;School of Science,Inner Mongolia University of Science and Technology,Baotou 014010 China;School of Life Science and Technology,Xidian University,Xi'an 710126 China)

机构地区：[1]内蒙古科技大学信息工程学院,内蒙古包头014010 [2]内蒙古科技大学理学院,内蒙古包头014010 [3]西安电子科技大学生命科学与技术学院,西安710126

出　　处：《内蒙古医学杂志》2023年第8期910-912,917,共4页Inner Mongolia Medical Journal

基　　金：国家自然科学基金(编号:82260359,81871430,81871426);内蒙古自然科学基金(编号:2020MS08059,2021MS08014)。

摘　　要：目的采用基于体素的静息态功能连接(RSFC)探索脑岛与全脑体素的异常区域,同时也给寻求治疗戒烟的患者提供新的靶点。方法采集25例青少年吸烟者和25例静息态功能磁共振图像者的脑岛RSFC。结果与对照组相比,青少年吸烟组的左腹侧前脑岛(vAI.L)和前额叶(PFC)之间的功能连接值减弱(FDR校正,P<0.01)。结论青少年吸烟引起脑岛的功能连接异常,同时与青少年的吸烟特征有着紧密的联系,为之后的戒烟机制提供了新的研究方向。Objective The use of voxel-based resting-state functional connectivity(RSFC)explores abnormal regions in the insula and whole-brain voxels,while also providing new targets for patients seeking treatment for smoking cessation.Methods Functional MRI images were acquired from25 adolescent smokers and 25 controls on the subject's insula RSFC.Results Diminished functional connectivity values between vAI.L and prefrontal lobes(PFC)in the adolescent smoking group compared to the control group(FDR corrected,P<0.01).Conclusion Adolescent smoking causes abnormal functional connectivity in the insula and is also strongly associated with adolescent smoking characteristics,providing a new research direction for subsequent smoking cessation mechanisms.

关 键 词：青少年 吸烟成瘾 静息态功能连接 脑岛 

分 类 号：R742[医药卫生—神经病学与精神病学]