Senolysis through thrombomodulation  

作　　者：Corey M.Webster Jan M.van Deursen 

机构地区：[1]Buck Institute for Research on Aging,Novato,CA,USA. [2]Cavalry Biosciences,Novato and San Francisco,CA,USA

出　　处：《Cell Research》2023年第8期575-576,共2页细胞研究（英文版）

摘　　要：In a recent study published in Cell Research,Pan et al.show that thrombomodulin(THBD),a cell surface glycoprotein activator of the thrombin-mediated MAPK pathway,is a key determinant of senescent cell fate.Using the FDA-approved THBD pathway inhibitor,vorapaxar,or depletion of THBD signaling,they show that inhibition or depletion of the THBD pathway acts as a novel senolytic mechanism and restores homeostasis in liver fibrosis models.

关 键 词：THROMBO HOMEOSTASIS 

分 类 号：Q2[生物学—细胞生物学]