骨髓浸润伴染色体异常的DLBCL患者临床特征及与预后的相关性分析  

Clinical Characteristics and Correlation with Prognosis of DLBCL with Bone Marrow Involvement and Chromosomal Abnormalities

作　　者：李香霖 关涛[1] 赵志强[1] 刘小兰[1] 王慧[1] 苏丽萍[1] 王列样[1] LI Xiang-Lin;GUAN Tao;ZHAO Zhi-Qiang;LIU Xiao-Lan;WANG Hui;SU Li-Ping;WANG Lie-Yang(Department of Hematology,Shanxi Province Cancer Hospital,Shanxi Hospital Affiliated to Cancer Hospital,Chinese Academy of Medical Sciences,Cancer Hospital Affiliated to Shanxi Medical University,Taiyuan 030000,Shanxi Province,China)

机构地区：[1]山西省肿瘤医院、中国医学科学院肿瘤医院山西医院、山西医科大学附属肿瘤医院血液内科,山西太原030000

出　　处：《中国实验血液学杂志》2023年第5期1366-1371,共6页Journal of Experimental Hematology

摘　　要：目的:探讨骨髓浸润伴染色体异常的弥漫大B细胞淋巴瘤(DLBCL)患者的临床特征,以及染色体异常程度与预后的相关性。方法:回顾性分析在山西省肿瘤医院诊断为骨髓浸润且具有完整染色体结果的88例DLBCL患者的临床资料,采用χ^(2)检验分析其临床特征,采用Kaplan-Meier方法进行无进展生存(PFS)和总体生存(OS)分析,log-rank方法进行比较分析。结果:88例患者中有31例检测出染色体异常(35.2%),其中复杂核型者15例(17.0%)。复杂核型患者BCL-2、BCL-6、C-MYC、Ki-67≥80%阳性检出率高,且多为双表达。生存分析发现复杂核型的DLBCL患者PFS和OS明显差于染色体正常及1-2条染色体异常患者。结论:骨髓浸润且染色体异常的DLBCL患者中,复杂核型患者的生存期更短。Objective:To investigate the clinical characteristics of diffuse large B-cell lymphoma(DLBCL)patients with bone marrow involvement and chromosome abnormalities,and further analyze the correlation between the degree of chromosome abnormality and prognosis.Methods:The clinical data of 88 patients diagnosed with DLBCL with bone marrow involvement and complete chromosomal findings in Shanxi Province Cancer Hospital were retrospectively analyzed.Theχ^(2)test was used to analyze their clinical characteristics,and the Kaplan-Meier method was used in PFS and OS,and log-rank method in comparison.Results:Chromosome abnormalities were detected in 31 of the 88 patients(35.2%),15 of whom had complex karyotype(17.0%).The positive rate of BCL-2,BCL-6,C-MYC and Ki-67≥80%was high in patients with complex karyotype,and most of them are double expressor lymphoma.Survival analysis showed that patients with complex karyotype of DLBCL had poorer PFS and OS compared to those with normal karyotype and 1-2 chromosomal abnormalities.Conclusion:In DLBCL patients with bone marrow involvement and chromosome abnormalities,patients with complex karyotype have a shorter survival time.

关 键 词：弥漫性大B细胞淋巴瘤 染色体异常 生存分析 预后 

分 类 号：R733.1[医药卫生—肿瘤]