Autologous bone marrow infusion via portal vein combined with splenectomy for decompensated liver cirrhosis: A retrospective study  

作　　者：Bao-Chi Liu Ming-Rong Cheng Lin Lang Lei Li Yan-Hui Si Ai-Jun Li Qing Xu Hui Zhang 

机构地区：[1]Department of Surgery,Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,China [2]He Nuo Medical Clinic,Shanghai New Hongqiao International Medical Center,Shanghai 201100,China [3]Department of Anorectal Surgery,The Third Affiliated Hospital of Guizhou Medical University,Duyun 558000,Guizhou Province,China [4]Department of Hepatobiliary Surgery,Oriental Hepatobiliary Surgery Hospital,Shanghai 200433,China [5]Department of Hepatobiliary Surgery,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China [6]Department of Hepatobiliary Surgery,Shanghai Oriental Hospital Affiliated to Tongji University,Shanghai 200120,China

出　　处：《World Journal of Gastrointestinal Surgery》2023年第9期1919-1931,共13页世界胃肠外科杂志（英文版）（电子版）

基　　金：Supported by Shenkang Hospital Development Center of Shanghai,China,No.SHDC12016129.

摘　　要：BACKGROUND In a previous study,autologous bone marrow infusion(ABMI)was performed in patients with decompensated liver cirrhosis(DLC)and acquired immunodefi-ciency syndrome and achieved good results,but whether splenectomy affected outcome was unclear.AIM To investigate the efficacy of ABMI combined with splenectomy for treatment of DLC.METHODS Eighty-three patients with DLC were divided into an intervention group(43 cases)and control group(40 cases)according to whether splenectomy was performed.The control group was treated with ABMI through the right omental RESULTS After ABMI,the prothrombin time,serum total bilirubin levels,ascites volume and model for end-stage liver disease score in both groups were significantly lower,while the albumin levels were significantly higher than before ABMI(P<0.01),but there were no significant differences between the groups(P>0.05).After ABMI,the white blood cell and platelets counts in both groups were significantly higher than before ABMI(P<0.01),and the counts in the intervention group were significantly higher than in the control group(P<0.01).After ABMI the CD4+and CD8+T cell counts in both groups were significantly higher than before ABMI(P<0.01).The CD8+T cell counts in the intervention group increased continuously and the increase had a shorter duration compared with control group.CONCLUSION ABMI through the portal vein in patients with DLC can significantly improve liver synthetic and secretory functions,and splenectomy promotes improvement of bone marrow hematopoietic and cellular immune functions.

关 键 词：Autologous bone marrow SPLENECTOMY Cell therapy CIRRHOSIS Cellular immunity 

分 类 号：R575.2[医药卫生—消化系统]