海参硫酸多糖与肠道菌群的相互作用及其调节糖脂代谢的研究进展  

Research Progress on Interaction between Sulfated Polysaccharides from Sea Cucumber and Gut Microbiota and Its Regulatory Effect on Glycolipid Metabolism

作　　者：桑雪 李莹 童瑶 于双 宋志远 李双双 赵前程 SANG Xue;LI Ying;TONG Yao;YU Shuang;SONG Zhiyuan;LI Shuangshuang;ZHAO Qiancheng(College of Food Science and Engineering,Dalian Ocean University,Dalian 116023,China;Dalian Key Laboratory of Marine Bioactive Substances Development and High Value Utilization,Dalian 116023,China;Liaoning Provincial Marine Healthy Food Engineering Research Centre,Dalian 116000,China;Collaborative Innovation Center of Provincial and Ministerial Co-construction for Marine Food Deep Processing,Dalian Polytechnic University,Dalian 116034,China;Key Laboratory of Biotechnology and Bioresources Utilization,Dalian Minzu University,Dalian 116650,China;Dalian Xinyulong Marine Organisms Seed Industry Technology Co.,Ltd.,Dalian 116200,China)

机构地区：[1]大连海洋大学食品科学与工程学院,辽宁大连116023 [2]大连市特色海洋功效成分开发与高值化利用重点实验室,辽宁大连116023 [3]辽宁省海洋健康食品工程研究中心,辽宁大连116000 [4]大连工业大学,海洋食品精深加工关键技术省部共建协同创新中心,辽宁大连116034 [5]大连民族大学生物技术与资源利用教育部重点实验室,辽宁大连116650 [6]大连鑫玉龙海洋生物种业科技股份有限公司,辽宁大连116200

出　　处：《食品科学》2023年第17期321-331,共11页Food Science

基　　金：大连市中央引导地方科技发展资金自由探索基础研究项目;辽宁省自然科学基金计划项目(2022-BS-275);辽宁省教育厅青年项目(LJKQZ20222401);辽宁省科技重大专项计划项目(2020JH1/10200001);国家重点研发计划“蓝色粮仓科技创新”专项(2018YFD0901004);生物技术与资源利用教育部重点实验室开放课题(KF2022007)。

摘　　要：海参作为重要的海洋食品和药物资源,其所含多糖是最重要的功效活性物质之一。硫酸基团在多糖的生物活性中发挥着重要的作用,海参硫酸多糖由于其不同的化学结构而可能特定影响某种肠道微生物的生长及相关代谢物的产生,而这有助于发挥多种健康作用。肠道菌群作为人体的一个复杂生态系统,在营养代谢等生命活动中发挥着不可替代的作用,而海参硫酸多糖可以作为益生元通过调节肠道菌群组成来改善菌群紊乱导致的疾病。本文在介绍海参硫酸多糖结构的基础上,重点阐述了其通过与肠道菌群相互作用影响糖脂代谢的最新相关研究进展。这些研究将有助于更好地理解海参硫酸多糖的健康作用机理,并为其作为功能性食品的应用提供科学依据。Sea cucumber,an important marine food and medicinal resource,contains polysaccharides,which are one of the most important active substances in it.Sulfate groups play an important role in the biological activity of polysaccharides,and sea cucumber sulfated polysaccharides may specifically affect the growth of certain intestinal microorganisms and the production of related metabolites due to their different chemical structures,which contribute to the variable health promoting effects.As a complex ecosystem of the human body,the intestinalflora plays an irreplaceable role in life activities such as nutritional metabolism.Sea cucumber sulfated polysaccharides can be used as prebiotics to alleviate diseases caused by intestinalflora disorder by regulating its composition.This review article summarizes the structures of sea cucumber sulfated polysaccharides,with a focus on the latest progress in research on their influence on glycolipid metabolism through the gut microbiota.These studies will contribute to a better understanding of the health promoting mechanism of sea cucumber sulfated polysaccharides and provide a scientific basis for their application in functional foods.

关 键 词：海参硫酸多糖 结构特征 肠道菌群 糖脂代谢 

分 类 号：TS254.1[轻工技术与工程—水产品加工及贮藏工程]