Efficacy of verbascoside,echinacoside,crenatoside on altitudeinduced fatigue in rats and possible mechanism  

作　　者：GUO Ziliang QIAN Qingyuan LI Xiaolin ZHU Yuting REN Jun LI Maoxing 

机构地区：[1]College of Pharmacy,Lanzhou University,Lanzhou 730030,China [2]Department of Pharmacy,the 940th Hospital of Joint Logistic Support Force of Chinese of the People's Liberation Army,Lanzhou 730050,China [3]Department of Pharmacy,3201 Hospital,Hanzhong 723000,China

出　　处：《Journal of Traditional Chinese Medicine》2023年第5期934-943,共10页中医杂志（英文版）

基　　金：Logistics Research Projects:the Project of Preparation of Crocetin Nanoparticles and Study on the Mechanism of Enhancing the Efficiency of Military Operations at High Altitude(CLB21J036);Top Cultivation Project:the Role of Crocetin in Improving Military Operations Efficiency in High Altitude Hypoxic Environments(2021yxky001);Youth Cultivation Project:Screening and Mechanism Study of Phenylethanol Glycosides and Their Metabolites Against High Altitude Hypoxia Activity(2021yxky060);Open Fund Project of the Collaborative Innovation Center Jointly Constructed by the Northwest China Tibet Medicine Province and Ministry:the Open Foundation of Northwest Collaborative Innovation Center for Traditional Chinese Medicine Co-constructed by Gansu Province and MOE of PRC(Xbzzy-2022-06);Gansu Provincial Health Industry Research Project:Study on the Anti-Hypoxia and Anti-fatigue Effects and Mechanisms of Crocin(GSWSKY2020-41);National Youth Fund:Study on the Dual Regulation of Vascular Endothelial Homeostasis Based on the PI3K/Akt Pathway-the Mechanism of Action of Zmyristosterone against Ischemic Stroke(82003982)。

摘　　要：OBJECTIVE:To study the efficacy and mechanism of three phenylethanoid glycosides(PhG s)(verbascoside,echinacoside,and crenatoside)on altitude-induced fatigue in rats.METHODS:Altitude-induced fatigue model rats were established in a large hypobaric chamber.Swimming time,energy storage substances,metabolic enzymes,and metabolites were used to evaluate the anti-fatigue activities and mechanism of three PhG s(verbascoside,echinacoside,and crenatoside)(150 mg/kg,intragastric administration)in the hypoxic environment.RESULTS:The three PhGs,especially verbascoside,could prolong the swimming time of rats,ameliorate the edema and inflammatory infiltration of liver and skeletal muscle,increase the level of energy storage substances,reduce the decomposition of proteins,and exhibit positive effects on the metabolism-related enzyme activity and metabolites.CONCLUSIONS:The PhG s,especially verbascoside,are very potential with anti-fatigue activity in hypoxia.The mechanism may be explained with regulation of energy metabolism and reduction of oxidative stress.

关 键 词：phenylethanoid glycosides VERBASCOSIDE HYPOXIA FATIGUE energy metabolism 

分 类 号：R285.5[医药卫生—中药学]