A new glance at autophagolysosomal-dependent or-independent function of transcriptional factor EB in human cancer  

作　　者：Ting Wang Yi Qin Zeng Ye De-sheng Jing Gui-xiong Fan Meng-qi Liu Qi-feng Zhuo Shun-rong Ji Xue-min Chen Xian-jun Yu Xiao-wu Xu Zheng Li 

机构地区：[1]Department of Pancreatic Surgery,Fudan University Shanghai Cancer Center,Shanghai,200032,China [2]Department of Oncology,Shanghai Medical College,Fudan University,Shanghai,200032,China [3]Shanghai Pancreatic Cancer Institute,Shanghai,200032,China [4]Pancreatic Cancer Institute,Fudan University,Shanghai,200032,China [5]Department of Hepatobiliary Surgery,The Third Affiliated Hospital of Soochow University,Changzhou,213000,China

出　　处：《Acta Pharmacologica Sinica》2023年第8期1536-1548,共13页中国药理学报（英文版）

基　　金：supported by grants from Shanghai Municipal Science and Technology Commission (20ZR1471100);National Natural Science Foundation of China (No.82141129,82173281,82172948,81972250,82172577 and U21A20374);Shanghai Municipal Science and Technology Major Project (21JC1401500);Scientific Innovation Project of Shanghai Education Committee (2019-01-07-00-07-E00057);Clinical Research Plan of Shanghai Hospital Development Center (SHDC2020CR1006A);Xuhui District Artificial Intelligence Medical Hospital Cooperation Project (2021-011).

摘　　要：Autophagy-lysosome system plays a variety of roles in human cancers.In addition to being implicated in metabolism,it is also involved in tumor immunity,remodeling the tumor microenvironment,vascular proliferation,and promoting tumor progression and metastasis.Transcriptional factor EB(TFEB)is a major regulator of the autophagy-lysosomal system.With the in-depth studies on TFEB,researchers have found that it promotes various cancer phenotypes by regulating the autophagolysosomal system,and even in an autophagy-independent way.In this review,we summarize the recent findings about TFEB in various types of cancer(melanoma,pancreatic ductal adenocarcinoma,renal cell carcinoma,colorectal cancer,breast cancer,prostate cancer,ovarian cancer and lung cancer),and shed some light on the mechanisms by which it may serve as a potential target for cancer treatment.

关 键 词：NEOPLASM autophagy-lysosomal system TFEB Protein Mammalian Target Of Rapamycin Complex 1 tumor progression METASTASIS 

分 类 号：R737.14[医药卫生—肿瘤]