Shati/Nat8l在神经系统中作用及机制的研究进展  

Advances in Understanding the Neurological Function and Mechanisms of Shati/Nat81

作　　者：周元青 刘海军 徐平 Zhou Yuanqing;Liu Haijun;Xu Ping(Neurology Department,Affiliated Hospital of Zunyi Medical University,Zunyi 563000;Brain Science Laboratory of Zunyi Medical University,Zunyi 563003)

机构地区：[1]遵义医科大学附属医院神经内科,遵义563000 [2]遵义医科大学脑科学实验室,遵义563003

出　　处：《国际老年医学杂志》2023年第5期613-616,共4页International Journal of Geriatrics

基　　金：国家自然科学基金(82060218);贵州省科技支撑项目(20204Y144);贵州省卫计委科学技术基金(gzwjkj2018-1-001);贵州省教育厅基础药理教育部重点实验室(遵义医学院)开放课题基金项目(黔教合KY字[2018]485);贵州省科技厅联合基金项目(黔科合LH字[2017]7121)。

摘　　要：Shati/Nat8l是具有N-乙酰基转移酶活性的N-乙酰转移酶-8样蛋白(Nat8l),在多个大脑区域表达,主要调节N-乙酰-L-天冬氨酸(NAA)的量,参与神经系统的神经发生、髓鞘形成、神经可塑性、神经营养因子调节、多巴胺能系统等的生理病理过程,与认知功能障碍等多种神经系统疾病的发病机制相关。本文综述Shati/Nat8l在神经系统中的作用及其分子机制,以期为神经系统疾病的诊治提供新方向。Shati/Nat8l,a notable N-acetyltransferase-8-like protein(Nat8l),orchestrates vital functions within the nervous system by modulating N-acetyltransferase activity.This activity is pivotal in regulating the concentration of N-acetyl-L-aspartate(NAA)across multiple cerebral regions.Beyond its enzymatic role,Shati/Nat8l exerts influence over critical physiological and pathological processes encompassing neurogenesis,myelinogenesis,neuroplasticity,regulation of neurotrophic factors,and modulation of the dopaminergic system.Intriguingly,its intricate involvement extends to the intricate landscape of neurological disorders,including cognitive impairments.This comprehensive paper illuminates the multifaceted role of Shati/Nat8l in the nervous system,un raveling its molecular mechanisms.By doing so,it not only broadens our comprehension but also points towards novel avenues for the diagnosis and therapeutic intervention of a spectrum of neurological disorders.

关 键 词：Shati/Nat8l N-乙酰-L-天冬氨酸 神经发生 神经可塑性 多巴胺能系统 髓鞘形成 

分 类 号：R741[医药卫生—神经病学与精神病学]