单细胞转录组测序在黑素瘤研究中的应用  

Application of single-cell RNA sequencing in melanoma research

作　　者：李婷婷[1] 关猛猛[1] 赵娟[1] 康晓静[1] Li Tingting;Guan Mengmeng;Zhao Juan;Kang Xiaojing(Department of Dermatology and Venereology,People′s Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Clinical Research Center for Dermatologic Diseases,Xinjiang Key Laboratory of Dermatology Research(XJYS1707),Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院皮肤性病科新疆皮肤病临床医学研究中心新疆皮肤病研究重点实验室(XJYS1707),乌鲁木齐830001

出　　处：《中华皮肤科杂志》2023年第10期977-981,共5页Chinese Journal of Dermatology

基　　金：新疆维吾尔自治区“天山创新团队计划”项目(2020D14006);新疆维吾尔自治区自然科学基金(2021D01C201)。

摘　　要：肿瘤异质性是黑素瘤组织的重要特征之一。单细胞转录组测序不仅能进一步揭示黑素瘤细胞异质性,且在分析黑素瘤发生发展规律、发现免疫治疗新靶点及揭示耐药机制等方面具有独特优势。本文综述单细胞转录组测序在黑素瘤研究中的应用。Tumor heterogeneity is one of the important characteristics of melanoma.Single-cell RNA sequencing can not only further reveal the heterogeneity of melanoma cells,but also has unique advantages in analyzing the occurrence and development of melanoma,finding new targets for immunotherapy and uncovering mechanisms of drug resistance.This review summarizes the application of single-cell transcriptome sequencing in melanoma research.

关 键 词：黑色素瘤 序列分析 RNA 转录组 单细胞分析 遗传异质性 肿瘤微环境 免疫疗法 抗药性 肿瘤 单细胞转录组测序 

分 类 号：R739.5[医药卫生—肿瘤]