Polylysine complexes and their biomedical applications  

作　　者：Haofang Zhu Rui Liu Yixuan Shang Lingyun Sun 

机构地区：[1]Department of Rheumatology and Immunology,Institute of Translational Medicine,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China

出　　处：《Engineered Regeneration》2023年第1期20-27,共8页再生工程（英文）

基　　金：supported by the Natural Science Foundation of Jiangsu Province (BK20210016);the National Key R&D Program of China (2020YFA0710800);the Key Program of National Natural Science Foundation of China (grant no.81930043);the Major International (Regional)Joint Research Project of China (grant no.81720108020);the Jiangsu Provincial Key Research and Development Program (BE2020621).

摘　　要：Poly-L-lysine(PLL)is a water-soluble biopolymer consist of repeating unit of L-lysine.It displays intrinsic non-antigenicity,antibacterial property,biocompatibility,and biodegradability,and facile synthesis procedure,there-fore has attracted particular attention in various biomedical and pharmaceutical applications.Following a brief introduction to PLL synthesis,this review focuses on the significant advances of PLL and PLL-derived complexes utilized in cargo delivery,tissue adhesives,and antibacterial materials.Meanwhile,this review summarized the modification and optimization of PLL complexes for further clinical translational studies.The final section dis-cusses the challenges and opportunities of PLL-based complexes in the biomedical areas.

关 键 词：POLYLYSINE cargo delivery BIOADHESIVE ANTIBACTERIAL BIOMEDICINE 

分 类 号：R318[医药卫生—生物医学工程]