Immunopathogenesis and immunomodulatory therapy for myocarditis  

作　　者：Wu He Ling Zhou Ke Xu Huihui Li James Jiqi Wang Chen Chen DaoWen Wang 

机构地区：[1]Division of Cardiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders,Wuhan 430030,China

出　　处：《Science China(Life Sciences)》2023年第9期2112-2137,共26页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China (81790624 and C-0052);Natural Science Foundation of Hubei Province (2020CFA016)。

摘　　要：Myocarditis is an inflammatory cardiac disease characterized by the destruction of myocardial cells, infiltration of interstitial inflammatory cells, and fibrosis, and is becoming a major public health concern. The aetiology of myocarditis continues to broaden as new pathogens and drugs emerge. The relationship between immune checkpoint inhibitors, severe acute respiratory syndrome coronavirus 2, vaccines against coronavirus disease-2019, and myocarditis has attracted increased attention. Immunopathological processes play an important role in the different phases of myocarditis, affecting disease occurrence, development, and prognosis. Excessive immune activation can induce severe myocardial injury and lead to fulminant myocarditis,whereas chronic inflammation can lead to cardiac remodelling and inflammatory dilated cardiomyopathy. The use of immunosuppressive treatments, particularly cytotoxic agents, for myocarditis, remains controversial. While reasonable and effective immunomodulatory therapy is the general trend. This review focuses on the current understanding of the aetiology and immunopathogenesis of myocarditis and offers new perspectives on immunomodulatory therapies.

关 键 词：MYOCARDITIS ETIOLOGY PATHOGEN IMMUNOPATHOGENESIS IMMUNOMODULATORY 

分 类 号：R542.21[医药卫生—心血管疾病]