儿童青少年抑郁障碍肥胖患病率及相关因素分析  

Obesity and related factors in children and adolescents with depressive disorder

作　　者：武士喜 刘志伟 张静静[1] 孙亮 杨荣春[1] WU Shi-xi;LIU Zhi-wei;ZHANG Jing-jing;SUN Liang;YANG Rong-chun(Department of Psychiatry,The Third People's Hospital of Fuyang,Fuyang 236015,China)

机构地区：[1]阜阳市第三人民医院精神科,236015

出　　处：《临床精神医学杂志》2023年第5期377-380,共4页Journal of Clinical Psychiatry

基　　金：2021年安徽省医疗卫生重点专科建设项目。

摘　　要：目的:探讨儿童青少年抑郁障碍患者的肥胖率及相关影响因素。方法:选取抑郁障碍儿童青少年患者757例,收集一般人口学资料及临床数据;评估非自杀性自伤(NSSI)行为;测量体质量及生化指标。结果:儿童青少年抑郁障碍患者的肥胖率为10.4%。肥胖组与非肥胖组比较,发病年龄、首次住院年龄、总病程、住院次数及体质量指数(BMI)、空腹血糖、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)及低密度脂蛋白(LDL-C)、NSSI行为、使用抗抑郁药物种类差异存在统计学意义(P<0.05)。肥胖与总病程、住院次数、空腹血糖、TG、TC、LDL-C及NSSI呈正相关;与年龄、首次住院年龄、HDL-C、使用几种抗抑郁药物及抗抑郁药物剂量呈负相关(P<0.05)。回归分析显示空腹血糖(OR=2.114,P=0.007)、TG(OR=2.086,P=0.001)及NSSI行为(OR=2.103,P=0.010)是抑郁障碍患儿伴肥胖的危险因素,而较高剂量的抗抑郁药(OR=0.970,P=0.015)是肥胖发生的保护性因素。结论:儿童青少年抑郁障碍患者肥胖率较高,且与空腹血糖、TG、NSSI行为及抗抑郁药服用剂量密切相关。Objective:To investigate the obesity rate and its influencing factors in children and adolescents with depressive disorder.Method:A total of 757 children and adolescents with depressive disorder were selected and their general demographic data and clinical data were collected.Non-suicidal self-injury(NSSI)behavior was evaluated.Body Mass and related biochemical indexes were measured.Results:The obesity rate among children and adolescents with depressive disorders was 10.4%.The obese group and the non-obese group showed significant differences in age of onset,age of first hospitalization,total disease duration,number of hospitalizations and body mass index(BMI),fasting blood glucose(FBG),triglyceride(TG),total cholesterol(TC),high density lipoprotein(HDL-C)and low-density lipoprotein(LDL-C),non-suicidal self-injury,and type of antidepressants used(P<0.05).Obesity was positively correlated with total disease duration,hospitalization times,FBG,TG,TC,LDL-C and NSSI;negatively correlated with age,age at first hospitalization,HDL-C,antidepressants numbers and antidepressant dose(P<0.05).Regression analysis showed that FBG(OR=2.114,P=0.007),TG(OR=2.086,P=0.001)and NSSI behavior(OR=2.103,P=0.010)were risk factors for obesity in children with depression,while higher doses of antidepressants(OR=0.970,P=0.015)were a protective factor for obesity.Conclusion:The obesity rate is high in children and adolescents with depressive disorder,which is closely related to FBG,TG,NSSI behavior and antidepressant dosage.

关 键 词：儿童 青少年 抑郁障碍 肥胖 患病率 

分 类 号：R749.9[医药卫生—神经病学与精神病学]