TRAF2 decreases lipid accumulation in hepatocytes under endoplasmic reticulum stress  

作　　者：Siqi Li Yang Li Xiaoxia Wang Zhixiong Xia Ronggui Hu 

机构地区：[1]School of Medicine,Guizhou University,Guiyang 550025,China [2]College of Life Science and Technology,Key Laboratory of Molecular Biophysics of MOE,and International Research Center for Sensory Biology and Technology of MOST,Huazhong University of Science and Technology,Wuhan 430074,China [3]Shanghai Institute of Immunology,Department of Immunology and Microbiology,Shanghai Jiao Tong University School of Medicine,Shanghai Jiao Tong University,Shanghai 200025,China [4]Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advance Study,University of Chinese Academy of Sciences,Hangzhou 310024,China [5]State Key Laboratory of Molecular Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai 200031,China

出　　处：《Acta Biochimica et Biophysica Sinica》2023年第9期1511-1514,共4页生物化学与生物物理学报（英文版）

基　　金：supported by the grants from the National Science and Technology Innovation 2030 Major Project of China(No.2021ZD0203900);the Ministry of Science and Technology of China(Nos.2021ZD0203900 and 2019YFA0802103);the Department of Science and Technology of Zhejiang Province(No.2021C03104);the Guangzhou Science Innovation and Development Program(No.201803010092);the Shenzhen-Hong Kong Institute of Brain Science(No.NYKFKT2019006).

摘　　要：The liver plays a pivotal role in the regulation of lipid and glucose metabolism.However,increased intake of nutrients,including glucose,fructose,and saturated fat,induces hepatic de novo lipogenesis and subclinical inflammation in the adipose tissue and liver[1].Deregulated nutrients perturb endoplasmic reticulum(ER)homeostasis and activate the stress response pathway unfolding protein response(UPR).There are three well-known signaling pathways in the UPR:inositol-requiring enzyme 1α/X-box binding protein 1(IRE1α/XBP1),protein kinase R-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α(PERK/eIF2α),and activating transcription factor 6(ATF6).

关 键 词：reticulum endoplasmic HOMEOSTASIS 

分 类 号：R57[医药卫生—消化系统]