Piperazine:Its role in the discovery of pesticides  

作　　者：Wei Zhang Shengxin Guo Lijiao Yu Ya Wang Yonggui Robin Chi Jian Wu 

机构地区：[1]National Key Laboratory of Green Pesticide,Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education,Guizhou University,Guiyang 550025,China [2]Division of Chemistry&Biological Chemistry,School of Physical&Mathematical Sciences,Nanyang Technological University,Singapore 637371,Singapore

出　　处：《Chinese Chemical Letters》2023年第8期69-75,共7页中国化学快报（英文版）

基　　金：The financial supports from National Natural Science Foundation of China(NSFC,Nos.32072445,21762012);the Program of Introducing Talents to Chinese Universities(No.D20023);the S&T Planning Project of Guizhou Province(No.[2017]5788);Graduate Research Fund in Guizhou Province(No.YJSKYJJ[2021]038).

摘　　要：Derivatives of piperazine,which is one of the most important heterocycles,are often used as linkers to connect active substructures that show promising bioactivities,especially in the field of agrochemicals.From 2000 to 2022,many piperazine-containing compounds were found to exhibit excellent activities against fungi,bacteria,insects,plant viruses,and weeds and have also been used as plant growth regulators.Currently,the development of novel pesticides to prevent the invasion of crop pathogens and ensure the quality and yields of crops is still needed.We herein investigated and summarized the role that piperazine plays in the discovery of pesticides to provide a comprehensive summary of the broad activities of piperazine derivatives in agricultural applications and offer a potential reference for novel pesticide design using piperazine-containing compounds.Moreover,structure–activity relationships(SARs)analyses of bioactive piperazine-containing compounds are also discussed for a deeper understanding.

关 键 词：PIPERAZINE Innovation of pesticides ACTIVITY Research review Structure-activity relationship 

分 类 号：O626[理学—有机化学] TQ450.1[理学—化学]