Self-assembly of phosphorylated peptide driven by Dy^(3+)  

作　　者：Hang Yang Yuting Xiong Minmin Li Zhiying Yang Peiran Meng Guangyan Qing 

机构地区：[1]CAS Key Laboratory of Separation Science for Analytical Chemistry,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Zhang Dayu School of Chemistry,Dalian University of Technology,Dalian 116024,China

出　　处：《Chinese Chemical Letters》2023年第8期180-183,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21922411 and 22174138);DICP Innovation Funding(No.DICP-RC201801 and I202008);the Dalian Outstanding Young Scientific Talent(No.2020RJ01).

摘　　要：Nature chooses phosphorylation as a key modification to modulate and program the functions of proteins.Various phosphorylated peptides(PPs)have been widely identified and investigated by biologists,but the possibility that PPs could become a building unit for artificial materials is neglected.Here we report for the first time a supramolecular assembly of PPs with the assistance of dysprosium ions(Dy^(3+)).Dy^(3+)bridges multiple phosphate groups in double-phosphorylated peptides(di-PPs),and braid these peptide chains into nanofibers.The assembly occurs inside nanochannels and blocks the channels,leading to prominent“ON–OFF”switching in transmembrane ionic current.The di-PPs’assembling process could be dynamically regulated by the addition or deletion of phosphate groups under the control of kinases or phosphatases.This study proves the huge potential of PPs being utilized as materials via self-assembling,which will promote the design of novel bio-inspired artificial materials and devices.

关 键 词：NANOCHANNEL PHOSPHORYLATION SELF-ASSEMBLY PEPTIDES DYSPROSIUM 

分 类 号：O641.3[理学—物理化学]