Functional biomaterials for comprehensive periodontitis therapy  

作　　者：Jiayi Luan Ruotao Li Weiguo Xu Huiying Sun Qiqi Li Di Wang Shujun Dong Jianxun Ding 

机构地区：[1]VIP Integrated Department,Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling,School and Hospital of Stomatology,Jilin University,Changchun 130021,China [2]Department of Hand and Foot Surgery,the First Hospital of Jilin University,Changchun 130061,China [3]Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China

出　　处：《Acta Pharmaceutica Sinica B》2023年第6期2310-2333,共24页药学学报（英文版）

基　　金：supported by the Hygiene and Health Appropriate Technology Promotion Project of Jilin Province (Grant No. 2020S014, China);the Science and Technology Project of Department of Finance of Jilin Province-2021 Health Talent Construction Project of Jilin Province (Grant No. jcsz2021893-1, China)。

摘　　要：Periodontitis is an inflammatory disease caused by bacterial infection directly, and the dysregulation of host immune-inflammatory response finally destroys periodontal tissues. Current treatment strategies for periodontitis mainly involve mechanical scaling/root planing(SRP), surgical procedures,and systemic or localized delivery of antimicrobial agents. However, SRP or surgical treatment alone has unsatisfactory long-term effects and is easy to relapse. In addition, the existing drugs for local periodontal therapy do not stay in the periodontal pocket long enough and have difficulties in maintaining a steady, effective concentration to obtain a therapeutic effect, and continuous administration always causes drug resistance. Many recent studies have shown that adding bio-functional materials and drug delivery systems upregulates the therapeutic effectiveness of periodontitis. This review focuses on the role of biomaterials in periodontitis treatment and presents an overview of antibacterial therapy, host modulatory therapy, periodontal regeneration, and multifunctional regulation of periodontitis therapy. Biomaterials provide advanced approaches for periodontal therapy, and it is foreseeable that further understanding and applications of biomaterials will promote the development of periodontal therapy.

关 键 词：Biomaterial Antibacterial effect Host modulation Periodontal regeneration Periodontitis therapy ANTI-OXIDANT ANTI-INFLAMMATION Drug delivery 

分 类 号：R783.1[医药卫生—口腔医学]