A myofiber-derived secreted factor for muscle regeneration  

作　　者：Fang Xiao Zheng Sun 

机构地区：[1]Department of Cadress Medical Care and Geriatrics,The Second Hospital,Cheeloo College of Medicine,Shandong University,Jinan,Shandong 250033,China [2]Department of Medicine-Division of Endocrinology,Diabetes,and Metabolism,Baylor College of Medicine,Houston,TX 77030,United States [3]Department of Molecular and Cellular Biology,Baylor College of Medicine,Houston,TX 77030,United States

出　　处：《Life Metabolism》2023年第4期5-6,共2页生命（代谢（英文）

摘　　要：A recent study shed light on transcriptional regulation of myofiber-derived Dkk3,a secreted protein involved in muscle differentiation,which has therapeutic implications in damage-induced muscle regeneration and obesity-associated muscle atrophy.Studies in muscle regeneration have been centered on resident muscle stem cells(MuSCs),also known as satellite cells.Upon muscle damage,quiescent MuSCs are activated to enter the cell cycle and start proliferation.They give rise to myogenic progenitor cells or myoblasts that differentiate into myocytes.Myocytes fuse with each other to form multinucleate myotubes that further mature to become myofibers[1].Each of the above stages is characterized by cascades of gene expression patterns orches-trated by distinct transcription factors receiving external signals from the microenvironment in alliance with physical interactions between the differentiating muscle cells and the other cell types in the muscle[2].

关 键 词：ATROPHY fiber OBESITY 

分 类 号：Q51[生物学—生物化学]