Effect of T-regulatory cells and interleukin-35, interleukin-10, and transforming growth factor-beta on diffuse large B-cell lymphoma  

作　　者：Hao Wu Hui-Cong Sun Gui-Fang Ouyang 

机构地区：[1]Department of Hematology,The First Affiliated Hospital of Ningbo University,Ningbo 315010,Zhejiang Province,China [2]Adult Internal Medicine,Ningbo Women and Children's Hospital,Ningbo 315012,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2023年第29期7075-7081,共7页世界临床病例杂志

基　　金：Supported by Zhejiang TCM Science and Technology Project,No.2023ZL653;Zhejiang Medical Science and Technology Plan Project-Clinical Research Application Project A,No.2021KY273。

摘　　要：BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is an aggressive non-Hodgkin lymphoma that affects B lymphocytes.It can develop in the lymph nodes and can be localized or generalized.Despite DLBCL being considered potentially curable,little research has been conducted on the relationship between the body's immune response and DLBCL.AIM To study the expression and significance of T-regulatory cells(Tregs)interleukin(IL)-35,IL-10,and transforming growth factor-beta(TGF-β)in DLBCL.METHODS Data from 82 patients with DLBCL who were initially admitted to The First Affiliated Hospital of Ningbo University(Zhejiang Province,China)between January 2017 and June 2022 and treated with standard first-line regimens were reviewed.Three patients were lost to follow-up;thus,79 patients were included in the statistical analysis and then divided into three groups according to the evaluation of clinical efficacy:Incipient(new-onset and treatment-naïve),effectively treated,and relapsed-refractory.Thirty healthy individuals were included in the control group.The expression of peripheral blood T lymphocytes and their associated factors IL-35,IL-10,and TGF-βin the four groups were observed.RESULTS In contrast to the successfully treated and normal control groups,both the incipient and relapse-refractory groups exhibited greater proportions of CD4-positive(+)Tregs(P<0.05),whereas the proportion of CD8+Tregs did not differ substantially between the groups.Serum levels of IL-35 and IL-10 in the incipient and relapsed-refractory groups were higher than those in the effectively treated and normal control groups(P<0.05).There was no statistically significant distinction in the expression level of TGF-βbetween the groups(P>0.05).The correlation between IL-35 and IL-10 concentrations was significantly positive,with a correlation coefficient of 0.531(P<0.05).The correlation between IL-35 and TGF-βconcentration was significantly positive,with a correlation coefficient of 0.375(P<0.05).The correlation between IL-10 and TGF-βconcentration was

关 键 词：Diffuse large B-cell lymphoma T-regulatory cells Interleukin-35 INTERLEUKIN-10 Transforming growth factorbeta Immune response 

分 类 号：R733.1[医药卫生—肿瘤]