粗梗胡椒化学成分的研究  

Study on the chemical constituents from Piper macropodum

作　　者：刘春月 冯艺璇 郭春林 刘思璇 路永富 李畅 裴月湖 LIU Chunyue;FENG Yixuan;GUO Chunlin;LIU Sixuan;LU Yongfu;LI Chang;PEI Yuehu(College of Pharmacy,Harbin Medical University,Harbin,Heilongjiang,150081 P.R.China)

机构地区：[1]哈尔滨医科大学药学院,黑龙江哈尔滨150081

出　　处：《华西药学杂志》2023年第5期533-536,共4页West China Journal of Pharmaceutical Sciences

摘　　要：目的 研究胡椒科胡椒属植物粗梗胡椒Piper macropodum C.DC.的化学成分。方法 采用多种柱色谱法结合HPLC法,分离纯化粗梗胡椒95%乙醇提取物,经理化性质和波谱数据解析,确定化合物的结构。结果 从95%乙醇提取物中分离鉴定了9个单体化合物,分别为preussomerin BG1(Ⅰ)、palmarumycin BG1(Ⅱ)、植物醇(Ⅲ)、4-烯丙基儿茶酚(Ⅳ)、schisanuilsonene A(Ⅴ)、opposit-4(15)-ene-1β,7-diol(Ⅵ)、iasiodiploclin(Ⅶ)、isochroman-1-one(Ⅷ)、茴香醛(Ⅸ)等。结论 化合物Ⅰ~Ⅱ、Ⅴ~Ⅷ为首次从该属植物中分离得到,所有化合物均为首次从该种植物中得到。OBJECTIVE To study the chemical constituents from Piper macropodum C.DC.METHODS Different types of column chromatography combined with HPLC were used to separate and purify the 95%ethanol extract of P.macropodum.The chemical properties and spectral data were analyzed to determine the structures of the obtained compounds.RESULTS Nine compounds were isolated and identified from the ethanol extract of P.macropodum,and they were identified as preussomerin BG1(I),palmarumycins BG1(Ⅱ),phytol(Ⅲ),4-allylcatechol(Ⅳ),schisanuilsonene A(Ⅴ),opposite-4(15)-ene-1β,7-diol(Ⅵ),iasiodiploclin(Ⅶ),isochroman-1-one(Ⅷ),and 4-methoxy-benzaldehyde(Ⅸ).CONCLUSION Compounds I-Ⅱ,Ⅴ-Ⅷwere isolated from this genus for the first time,and all the compounds were isolated from this plant for the first time.

关 键 词：粗梗胡椒 胡椒科 胡椒属 化学成分 结构鉴定 柱色谱法 高效液相色谱法 

分 类 号：R914[医药卫生—药物化学]