颅缝间充质干细胞在颅缝早闭症中的研究进展  

Research progress of cranial suture mesenchymal stem cells in craniosynostosis

作　　者：岳莹莹 靳小雷 Yue Yingying;Jin Xiaolei(Fourth Department of Craniomaxillofacial Surgery,Plastic Surgery Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100144,China)

机构地区：[1]中国医学科学院北京协和医学院整形外科医院颅颌面四科,北京100144

出　　处：《中华整形外科杂志》2023年第9期1028-1034,共7页Chinese Journal of Plastic Surgery

摘　　要：颅缝间充质干细胞是一个异质性颅面干细胞群体,具有自我更新和多向分化能力,在颅骨生长发育、稳态维持、损伤修复等诸多生理过程中发挥着重要作用。以往对间充质干细胞或骨骼干细胞的研究主要集中在长骨上,颅骨领域相关研究相对较少。该文对颅缝间充质干细胞的发现、提取与鉴定及其生物学特性进行了总结,对颅缝间充质干细胞在颅缝早闭症发病机制及治疗中的最新研究进展进行了综述。Cranial suture mesenchymal stem cells are a heterogeneous population of craniofacial stem cells with self-renewal and multi-lineage differentiation capabilities.These cells play a crucial role in various physiological processes,including skull growth and development,maintenance of homeostasis,and injury repair.Previous studies on mesenchymal stem cells or skeletal stem cells have mainly focused on long bones,while relevant studies in the field of cranial bone research are quite limited.This paper provides a comprehensive summary of the discovery,extraction,and identification of cranial suture mesenchymal stem cells,along with an overview of their biological characteristics.Additionally,it reviews the latest advancements in understanding the role of cranial suture mesenchymal stem cells in the pathogenesis and treatment of craniosynostosis.

关 键 词：颅缝早闭 间充质干细胞 颅缝 骨骼再生 

分 类 号：R651.1[医药卫生—外科学]