MRI研究轻度认知障碍大脑连接改变及其机制进展  

Progresses of MRI researches on brain connectivity changes and mechanisms of mild cognitive impairment

作　　者：李艳[1] 邵永佳 席芊[1] 王培军[2] LI Yan;SHAO Yongjia;XI Qian;WANG Peijun(Department of Radiology,Shanghai East Hospital,Tongji University,Shanghai 200120,China;Department of Radiology,Tongji Hospital of Tongji University,Shanghai 200065,China)

机构地区：[1]同济大学附属东方医院医学影像科,上海200120 [2]同济大学附属同济医院医学影像科,上海200065

出　　处：《中国医学影像技术》2023年第10期1583-1586,共4页Chinese Journal of Medical Imaging Technology

基　　金：上海市科学技术委员会科技计划项目(20Y11911700);上海市浦东新区卫生系统领先人才培养计划(PWRl2022-05)。

摘　　要：阿尔茨海默病(AD)是进行性发展的神经退行性疾病;轻度认知障碍(MCI)是正常衰老与痴呆之间的过渡状态,为预防性治疗AD的关键阶段。弥散张量成像(DTI)和血氧水平依赖功能MRI(BOLD-fMRI)常用于评估大脑结构及功能连接及解释其相关机制。本文就MRI研究MCI大脑连接改变及其机制进展进行综述。Alzheimer's disease(AD)is a progressive neurodegenerative disease.Mild cognitive impairment(MCI)is a transitional state between normal aging and dementia,also the critical stage for preventive treatment of AD.Diffusion tensor imaging(DTI)and blood oxygenation level dependent functional MRI(BOLD-fMRI)were commonly used to evaluate structural and functional connectivity of brain and explain related mechanisms.The progresses of MRI researches on brain connectivity changes and mechanisms of MCI were reviewed in this article.

关 键 词：认知障碍 阿尔茨海默病 磁共振成像 

分 类 号：R741[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]